胶束
动态光散射
水溶液
泊洛沙姆
化学
水动力半径
聚合数
荧光
化学工程
胶束溶液
扫描电子显微镜
分析化学(期刊)
临界胶束浓度
色谱法
聚合物
有机化学
材料科学
共聚物
纳米颗粒
物理
量子力学
工程类
复合材料
作者
Rajib Basak,Ranjini Bandyopadhyay
出处
期刊:Langmuir
[American Chemical Society]
日期:2013-03-19
卷期号:29 (13): 4350-4356
被引量:243
摘要
Three drugs, Ibuprofen, Aspirin and Erythromycin, are encapsulated in spherical Pluronic F127 micelles.The shapes and the size distributions of the micelles in dilute, aqueous solutions, with and without drugs, are ascertained using cryo-Scanning Electron Microscopy and Dynamic Light Scattering (DLS) experiments, respectively.Uptake of drugs above a threshold concentration is seen to reduce the critical micellization temperature of the solution.The mean hydrodynamic radii and polydispersities of the micelles are found to increase with decrease in temperature and in the presence of drug molecules.The hydration of the micellar core at lower temperatures is verified using fluorescence measurements.Increasing solution pH leads to the ionization of the drugs incorporated in the micellar cores.This causes rupture of the micelles and release of the drugs into the solution at the highest solution pH value of 11.36 investigated here and is studied using DLS and fluorescence spectrocopy.
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