NMDA受体
谷氨酸受体
神经退行性变
神经科学
受体
封锁
细胞凋亡
神经递质
生物
中枢神经系统
医学
药理学
内科学
疾病
生物化学
作者
Chrysanthy Ikonomidou,Frank R. van den Bosch,Michael Miksa,Petra Bittigau,Jessica Vöckler,Krikor Dikranian,Tatyana Tenkova,Vanya Stefovska,Lechosław Turski,John W. Olney
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1999-01-01
卷期号:283 (5398): 70-74
被引量:2004
标识
DOI:10.1126/science.283.5398.70
摘要
Programmed cell death (apoptosis) occurs during normal development of the central nervous system. However, the mechanisms that determine which neurons will succumb to apoptosis are poorly understood. Blockade of N -methyl- d -aspartate (NMDA) glutamate receptors for only a few hours during late fetal or early neonatal life triggered widespread apoptotic neurodegeneration in the developing rat brain, suggesting that the excitatory neurotransmitter glutamate, acting at NMDA receptors, controls neuronal survival. These findings may have relevance to human neurodevelopmental disorders involving prenatal (drug-abusing mothers) or postnatal (pediatric anesthesia) exposure to drugs that block NMDA receptors.
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