医学
亚临床感染
内科学
心脏病学
斑点追踪超声心动图
利钠肽
射血分数
心力衰竭
作者
Jülide Yağmur,Serpil Şener,Nusret Açıkgöz,Mehmet Cansel,Ertuğrul Kurtoğlu,Yelda Karıncaoğlu,Hakan Taşolar,Yasin Karakuş,Haşan Pekdemir,Рамазан Оздемир
出处
期刊:European journal of echocardiography
[Oxford University Press]
日期:2011-06-14
卷期号:12 (7): 536-541
被引量:35
标识
DOI:10.1093/ejechocard/jer088
摘要
The aim of this study was to evaluate the left ventricular (LV) systolic strain by speckle tracking echocardiography (STE) in order to provide the early detection of myocardial dysfunction in patients with Behcet's disease (BD). We also aimed to examine the relationship between LV systolic strain and N-terminal pro-B type natriuretic peptide (NT-proBNP), which is a cardiac biomarker of ventricular dysfunction. Longitudinal and circumferential systolic strain assessed by STE was obtained in 32 BD patients and 27 age-matched controls. NT-proBNP levels were also measured in all subjects. Regional and mean longitudinal strain (−17.8 ± 2.7 vs. −20.5 ± 1.8%; P < 0.0001) was significantly lower in BD patients when compared with the healthy controls. Whereas regional and mean circumferential strain values (−22.0 ± 1.6 vs. −22.2 ± 2.3%; P = 0.62) did not reveal a significant difference between the patients and the controls. NT-proBNP was significantly higher in the patients than in the controls (65.18 ± 84.51 vs. 30.84 ± 14.75 pg/mL; P = 0.003). Linear regression analyses revealed only NT-proBNP as the independent correlate of mean LV longitudinal strain (R = 0.603, P = 0.001). Longitudinal myocardial systolic function assessed by STE, which is a sensitive marker of subclinical ventricular dysfunction is impaired in BD. Increased NT-proBNP levels may be a sign of subclinical ventricular dysfunction in these patients.
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