生物
互补DNA
基因
限制性片段长度多态性
南方斑点
成纤维细胞生长因子
遗传学
染色体
限制性片段
基因组DNA
分子生物学
碱性成纤维细胞生长因子
生长因子
基因型
受体
作者
Ayalew Mergia,Roger L. Eddy,Judith A. Abraham,John C. Fiddes,Thomas B. Shows
标识
DOI:10.1016/s0006-291x(86)80545-9
摘要
Basic and acidic fibroblast growth factor (FGF) are related both structurally and functionally. A bovine basic FGF cDNA and a human acidic FGF genomic fragment were used as hybridization probes in Southern blot analysis of DNAs isolated from a panel of 30 mouse-human cell hybrids. The gene encoding basic FGF was assigned to human chromosome 4, and the gene for acidic FGF to human chromosome 5. The two growth factors which are presumed to have a common evolutionary ancestor are therefore not linked. A HindIII restriction fragment length polymorphism was detected for human basic FGF.
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