Mitochondrial metabolism of glutamine and glutamate and its physiological significance.

谷氨酰胺 谷氨酸受体 新陈代谢 线粒体 生物 生物化学 化学 神经科学 氨基酸 受体
作者
Zoran Kovačević,J D McGivan
出处
期刊:Physiological Reviews [American Physiological Society]
卷期号:63 (2): 547-605 被引量:351
标识
DOI:10.1152/physrev.1983.63.2.547
摘要

Mitochondrial metabolism of glutamine and glutamate and its physiological significance.Z Kovacevic, and J D McGivanZ Kovacevic, and J D McGivanPublished Online:01 Apr 1983https://doi.org/10.1152/physrev.1983.63.2.547MoreSectionsPDF (9 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByRecent Progress in the Discovery of Allosteric Inhibitors of Kidney-Type Glutaminase3 July 2018 | Journal of Medicinal Chemistry, Vol. 62, No. 1Metabolic Reprogramming in Modulating T Cell Reactive Oxygen Species Generation and Antioxidant Capacity16 May 2018 | Frontiers in Immunology, Vol. 9Metabolomics approach discriminates toxicity index of pyrazinamide and its metabolic products, pyrazinoic acid and 5-hydroxy pyrazinoic acid20 April 2017 | Human & Experimental Toxicology, Vol. 37, No. 4Glutamate Dehydrogenase as a Neuroprotective Target Against Neurodegeneration22 January 2018 | Neurochemical Research, Vol. 340Cancer metabolism in space and time: Beyond the Warburg effectBiochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1858, No. 8Glutamine Suppresses DNFB-Induced Contact Dermatitis by Deactivating p38 Mitogen–Activated Protein Kinase via Induction of MAPK Phosphatase-1Journal of Investigative Dermatology, Vol. 133, No. 3Bolus Oral Glutamine Protects Rats against CPT-11-Induced Diarrhea and Differentially Activates Cytoprotective Mechanisms in Host Intestine but Not TumorThe Journal of Nutrition, Vol. 138, No. 4Hepatic Glutamine Transport and Metabolism22 November 2006Interorgan ammonia, glutamate, and glutamine trafficking in pigs with acute liver failureLars M. Ytrebø, Sambit Sen, Christopher Rose, Gabrie A. M. Ten Have, Nathan A. Davies, Stephen Hodges, Geir I. Nedredal, Manuel Romero-Gomez, Roger Williams, Arthur Revhaug, Rajiv Jalan, and Nicolaas E. P. Deutz1 September 2006 | American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 291, No. 3Overexpression of catalase or Bcl-2 alters glucose and energy metabolism concomitant with dexamethasone resistanceBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol. 1693, No. 1Intestinal glutaminase activity is increased in liver cirrhosis and correlates with minimal hepatic encephalopathyJournal of Hepatology, Vol. 41, No. 1Expression of recombinant human l-glutaminase in Escherichia coli: polyclonal antibodies production and immunological analysis of mouse tissuesBiochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1648, No. 1-2Human cutaneous melanoma expresses a significant phosphate-dependent glutaminase activity: A comparison with the surrounding skin of the same patient1 January 2003 | Cell Biochemistry and Function, Vol. 21, No. 1Cell Metabolism, Animal15 January 2003New targets of β-catenin signaling in the liver are involved in the glutamine metabolism25 November 2002 | Oncogene, Vol. 21, No. 54Exercise-induced immunodepression– plasma glutamine is not the linkNatalie Hiscock, and Bente Klarlund Pedersen1 September 2002 | Journal of Applied Physiology, Vol. 93, No. 3Regulation of mitochondrial glutamine/glutamate metabolism by glutamate transport: studies with 15NTomas Welbourne, and Itzhak Nissim1 May 2001 | American Journal of Physiology-Cell Physiology, Vol. 280, No. 5Glutamine and arginine: immunonutrients for improved healthMedicine & Science in Sports & Exercise, Vol. 32, No. SupplementHuman kidney and liver gluconeogenesis: evidence for organ substrate selectivityMichael Stumvoll, Christian Meyer, Gabriele Perriello, Maryl Kreider, Stephen Welle, and John Gerich1 May 1998 | American Journal of Physiology-Endocrinology and Metabolism, Vol. 274, No. 5Transcriptional regulation of the hepatic glutaminase gene in the streptozotocin-diabetic ratInternational Journal of Biochemistry, Vol. 26, No. 2Mechanisms of ammonia and ammonium ion toxicity in animal cells: Transport across cell membranesJournal of Biotechnology, Vol. 30, No. 3Respiration in the muscle mitochondria of the mudskipper, Boleophthalmus boddaertiComparative Biochemistry and Physiology Part B: Comparative Biochemistry, Vol. 104, No. 4Effect of dietary supplementation with glutamic acid or glutamine on the splanchnic and muscle metabolism of glucogenic amino acids in the ratThe Journal of Nutritional Biochemistry, Vol. 4, No. 4Glutamate production in islets of Langerhans: Properties of phosphate-activated glutaminaseMetabolism, Vol. 41, No. 12Enhanced glutamine and glucose metabolism in cultured rat splenocytes stimulated by phorbol myristate acetate plus ionomycinMetabolism, Vol. 41, No. 9Oxidation of cytosolic NADH by the malate-aspartate shuttle in HOH13 human hepatoma cellsInternational Journal of Biochemistry, Vol. 24, No. 2Plasma and jejunal glutamine levels after extensive small bowel resection in dogsClinical Nutrition, Vol. 11, No. 1The stability of L-glutamine in total parenteral nutrition solutionsClinical Nutrition, Vol. 10, No. 4Investigation on phosphate dependent glutaminase (EC 3.5.1.2) activity in host tissues of EAC-bearing mice and response of liver EC 3.5.1.2 on Cu-ATP therapyCancer Letters, Vol. 58, No. 1-2Effects of corticosteroid on the transport and metabolism of glutamine in rat skeletal muscleBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol. 1092, No. 3Glutamine and glucose metabolism in rat splenocytes and mesenteric lymph node lymphocytesG. Y. Wu, C. J. Field, and E. B. Marliss1 January 1991 | American Journal of Physiology-Endocrinology and Metabolism, Vol. 260, No. 1Effect of B- and T-cell mitogens on the maximum activities of hexokinase, lactate dehydrogenase, citrate synthase and glutaminase in bone marrow cells and thymocytes of the rat during four hours of cultureInternational Journal of Biochemistry, Vol. 23, No. 9The effect of pH on the toxicity of ammonia to a murine hybridomaJournal of Biotechnology, Vol. 15, No. 1-231P-NMR studies of glucose and glutamine metabolism in cultured mammalian cellsBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol. 1051, No. 2Inhibition of human cancer cell growth by periodate-oxidized 3-aminopyridine adenine dinucleotide phosphateInternational Journal of Biochemistry, Vol. 22, No. 11Valproate-induced hyperammonemia of renal origin. Effects of valproate on glutamine transport in rat kidney mitochondriaBiochemical Pharmacology, Vol. 38, No. 22Simultaneous synthesis and degradation of glutamine in isolated rat liver cells. Effect of vasopressinBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol. 1014, No. 2End products of glutamine oxidation in MC-29 virus-induced chicken hepatoma mitochondriaBiochemical Medicine and Metabolic Biology, Vol. 42, No. 2Intestinal glutamine metabolismMetabolism, Vol. 38, No. 8Regulation of leucine transport and oxidation in peripheral human lymphocytes by glutamineMetabolism, Vol. 38, No. 8S-aminoethyl-l-cysteine transaminase from bovine brain: purification to homogeneity and assay of activity in different regions of the brainNeurochemistry International, Vol. 15, No. 3Catabolic Control of Mammalian Cell Culture1 September 1988 | Nature Biotechnology, Vol. 6, No. 9Glucose, glutamine, and ketone-body metabolism in human enterocytesMetabolism, Vol. 37, No. 6Isolation of a cDNA for rat brain glutaminaseMolecular Brain Research, Vol. 3, No. 3Research articleBiochimie, Vol. 70, No. 6Phosphate-dependent glutaminase in the human term placental mitochondriaBiochemical Medicine and Metabolic Biology, Vol. 39, No. 3Malate-citrate cycle during glycolysis and glutaminolysis in Ehrlich ascites tumor cellsBiochimie, Vol. 69, No. 5Postoperative alterations in interorgan glutamine exchange in enterectomized dogsJournal of Surgical Research, Vol. 42, No. 2Transamination of l-cystathionine and related compounds by bovine brain glutamine transaminaseNeurochemistry International, Vol. 10, No. 3Glutamine metabolism in the avian host bearing transplantable hepatomatous growth induced by MC-29 virusInternational Journal of Biochemistry, Vol. 18, No. 2Potassium-stimulated efflux of radiolabeled products formed from l-[14c(u)-glutamine in vitro by the saccule of the rainbow trout (Salmo Gairdnerii R)Comparative Biochemistry and Physiology Part A: Physiology, Vol. 84, No. 2The pathway of glutamate oxidation in isolated mitochondria from the avian hepatomatous growth induced by MC-29 virusComparative Biochemistry and Physiology Part B: Comparative Biochemistry, Vol. 85, No. 2Support of respiration and citrulline synthesis by isolated hepatic mitochondria from Squalus acanthias by acyl-coas and other nitrogen-donating substratesComparative Biochemistry and Physiology Part B: Comparative Biochemistry, Vol. 85, No. 4Transamination pathways influencing l-glutamine and l-glutamate oxidation by rat enterocyte mitochondria and the subcellular localization of l-alanine aminotransferase and l-aspartate aminotransferaseBiochimica et Biophysica Acta (BBA) - General Subjects, Vol. 843, No. 1-2The significance of the attachment of rat kidney glutaminase to the inner mitochondrial membraneBiochimica et Biophysica Acta (BBA) - General Subjects, Vol. 801, No. 3Characteristics of glutamic acid transport by rabbit intestinal brush-border membrane vesicles. Effects of Na+-, K+-and H+-gradientsBiochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 775, No. 2 More from this issue > Volume 63Issue 2April 1983Pages 547-605 Copyright & PermissionsCopyright © 1983 by American Physiological Societyhttps://doi.org/10.1152/physrev.1983.63.2.547PubMed6132422History Published online 1 April 1983 Published in print 1 April 1983 Metrics
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