End-stage renal failure and regulatory activities of CD4+CD25bright+FoxP3+ T-cells

Background. The defensive immune system in patients with end-stage renal failure is impaired at multiple levels. This state of immune incompetence is associated with continuous activation of the immune system. An additional explanation for this state of activation may be the disturbed function of CD4 + CD25 bright+ FoxP3 + regulatory T-cells.