医学
类胰蛋白酶
过敏反应
尸检
免疫组织化学
病理
免疫球蛋白E
抗体
肥大细胞
免疫学
过敏
作者
Motoki Osawa,Fumiko Satoh,Hidekazu Horiuchi,Wei Tian,Nobuko Kugota,Iwao Hasegawa
出处
期刊:Legal Medicine
[Elsevier]
日期:2008-05-01
卷期号:10 (3): 143-147
被引量:42
标识
DOI:10.1016/j.legalmed.2007.10.002
摘要
This report documented three autopsy cases involving fatal shock during intravenous injection of therapeutic and diagnostic agents in a hospital setting. For postmortem diagnosis, clinical laboratory parameters for anaphylaxis, specificity of antibodies for allergens and mast cell numbers in tissue sections were examined. Elevated plasma tryptase levels were evident in the three adult males; two of the three victims displayed elevated IgE levels. However, immunoassay failed to detect antibodies specific to the relevant agent. Double immuno-staining was performed employing anti-tryptase and anti-chymase monoclonal antibodies in order to count mast cells in lung sections. Increased numbers of mast cells were observed in anaphylactic tissues, which was particularly true for chymase-positive cells, in comparison with tissues associated with acute traumatic deaths. In addition to findings at autopsy, positive data obtained by laboratory examinations and immunohistochemical analyses indicated that fatal systemic anaphylaxis occurred during intravenous injection of clinical agents.
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