低密度脂蛋白受体
LRP1B型
受体
极低密度脂蛋白
信号转导
脂蛋白
载脂蛋白B
载脂蛋白E
生物
低密度脂蛋白受体相关蛋白8
细胞生物学
功能(生物学)
低密度脂蛋白
胆固醇
遗传学
生物化学
内科学
医学
疾病
作者
Johannes Nimpf,Wolfgang J. Schneider
标识
DOI:10.1016/s1388-1981(00)00155-4
摘要
The discovery of an ever growing number of low density lipoprotein (LDL) receptor gene family members has triggered research into many different directions. Here we first summarize the results of classical studies on the role of the LDL receptor in cholesterol transport, the structure/function relationships delineated with the help of LDL receptor mutations in familial hypercholesterolemia, and the elegant way in which cells regulate cholesterol at the transcriptional level. The second part deals with a multifunctional, structurally very close relative, the very low density lipoprotein (VLDL) receptor. While it is involved in lipoprotein transport in certain tissues and species, detailed studies on its function have generated new knowledge about the growing spectrum of ligands and about exciting and unexpected aspects of receptor biology. In particular, these investigations have elucidated the roles of LDL receptor gene family members in ligand-mediated signal transduction. In the third part of this review article, we provide first insight into the roles of the VLDL receptor and of another small relative, the so-called apolipoprotein E receptor-2, in such signaling processes. These findings suggest that to date, only the tip of an iceberg has been uncovered.
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