Sepsis in children

败血症 医学 重症监护医学 内科学
作者
Adrian Plunkett,J. Tong
标识
DOI:10.1136/bmj.h3017
摘要

#### The bottom line Sepsis is a clinical syndrome resulting from a dysregulated systemic inflammatory response to infection.1 It is characterised by a generalised pro-inflammatory cascade, which may lead to widespread tissue injury.2 It encompasses a clinical spectrum of severity, including severe sepsis, septic shock, and multi-organ failure.3 Sepsis is a leading cause of morbidity and mortality in children worldwide.4 International consensus guidelines define sepsis as the presence of systemic inflammatory response syndrome plus suspected or proven infection.3 A more pragmatic definition of sepsis has been proposed—that sepsis is a systemic response to infection with the presence of some degree of organ dysfunction.5 This definition is not currently widely accepted, but new criteria are under discussion and due to be published later in the year. Global data on sepsis in children are incomplete, but it is estimated that infection accounts for most deaths (almost 60%) in children aged under 5 years.4 The World Health Organization has stated that the four big causes of death in children worldwide are infectious diseases: pneumonia (1.9 million deaths/year), diarrhoea (1.6 million deaths/year), malaria (1.1 million deaths/year), and measles (550 000 deaths/year).6 The largest epidemiological reports of the incidence …
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
奇尔韦尔发布了新的文献求助10
1秒前
2秒前
2秒前
叶明昭完成签到,获得积分10
3秒前
高工完成签到,获得积分10
3秒前
ddsdd发布了新的文献求助10
3秒前
4秒前
4秒前
4秒前
ycc完成签到,获得积分20
5秒前
掉头发的小白完成签到,获得积分10
5秒前
5秒前
默默的紫真完成签到,获得积分10
6秒前
LYD发布了新的文献求助10
6秒前
6秒前
6秒前
不懈奋进应助坦率续采纳,获得30
7秒前
666发布了新的文献求助10
7秒前
ww完成签到,获得积分10
7秒前
深情安青应助温暖南莲采纳,获得10
8秒前
wu完成签到,获得积分10
9秒前
9秒前
脑洞疼应助温水采纳,获得10
9秒前
顾矜应助dove采纳,获得10
10秒前
练习时长两年半应助XXXX采纳,获得10
10秒前
贪玩的书白完成签到,获得积分20
11秒前
11秒前
小巫发布了新的文献求助10
11秒前
Jasper应助Drew采纳,获得10
12秒前
12秒前
星辰大海应助乘风破浪采纳,获得10
12秒前
12秒前
12秒前
13秒前
ixueyi发布了新的文献求助10
13秒前
美兮完成签到,获得积分10
13秒前
Deadman完成签到,获得积分10
13秒前
wu发布了新的文献求助10
13秒前
顺心的书包完成签到,获得积分10
14秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974712
求助须知:如何正确求助?哪些是违规求助? 3519159
关于积分的说明 11197254
捐赠科研通 3255257
什么是DOI,文献DOI怎么找? 1797724
邀请新用户注册赠送积分活动 877130
科研通“疑难数据库(出版商)”最低求助积分说明 806132