Adrenal surgery for bilateral primary aldosteronism: an international retrospective cohort study

Primary aldosteronism is the most common form of endocrine hypertension. The condition is diagnosed in around 6% of all patients with endocrine hypertension1 and is associated with a particularly severe form of hypertension that is often resistant to standard treatment.2 Unilateral forms, mostly caused by an aldosterone-producing adenoma, represent around a third of cases and are treated by unilateral adrenalectomy.3 This patient group have excellent long-term outcomes with normalised blood pressure and, compared with patients with primary hypertension, improved cardiovascular outcomes and all-cause mortality.