Durable Response to Trametinib in an Infant With ERC1-BRAF Infantile Fibrosarcoma-Like Tumor: A Case Report and Literature Review of BRAF-Altered Infantile Fibrosarcoma-Like Tumors

Article Tools CASE REPORTS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/PO.22.00200 JCO Precision Oncology no. 6 (2022) e2200200. Published online September 14, 2022. PMID: 36103644 Durable Response to Trametinib in an Infant With ERC1-BRAF Infantile Fibrosarcoma-Like Tumor: A Case Report and Literature Review of BRAF-Altered Infantile Fibrosarcoma-Like Tumors Antoine Gourmel, MD1xAntoine GourmelSearch for articles by this author; Alexandre Rouette , PhD2xAlexandre RouetteSearch for articles by this author; Naciba Benlimame, PhD3xNaciba BenlimameSearch for articles by this author; Ramy El-Jalbout, MD4xRamy El-JalboutSearch for articles by this author; Mireille Dubé, MD5xMireille DubéSearch for articles by this author; Yves Théorêt, PhD6xYves ThéorêtSearch for articles by this author; Nelson Piché , MD7xNelson PichéSearch for articles by this author; Sébastien Labonté, MD8xSébastien LabontéSearch for articles by this author; Daniel Sinnett , PhD9xDaniel SinnettSearch for articles by this author; Sonia Cellot , MD, PhD1,9xSonia CellotSearch for articles by this author; Dorothée Dal-Soglio, MD10xDorothée Dal-SoglioSearch for articles by this author; Valérie Larouche, MD11xValérie LaroucheSearch for articles by this author; and Thai Hoa Tran , MD1,9xThai Hoa TranSearch for articles by this author Show More 1Division of Pediatric Hematology-Oncology, Charles-Bruneau Cancer Centre, Centre Hospitalier Universitaire (CHU) Sainte-Justine, Université de Montreal, Montreal, QC, Canada2Molecular Diagnostics Laboratory, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire (CHU) Sainte-Justine, Montréal, QC, Canada3Research Pathology Facility, Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada4Department of Radiology, Centre Hospitalier Universitaire (CHU) Sainte-Justine, Montreal, QC, Canada5Department of Medical Imaging, Centre Hospitalier Universitaire (CHU) de Québec, Québec, QC, Canada6Clinical Pharmacology Laboratory, OPTILAB and Research Center, Centre Hospitalier Universitaire (CHU) Sainte-Justine, Montréal, QC, Canada7Division of Paediatric Surgery, Centre Hospitalier Universitaire (CHU) Sainte-Justine, Montréal, QC, Canada8Department of Pathology, Centre Hospitalier Universitaire (CHU) de Québec, Québec, QC, Canada9Department of Pediatrics, Centre Hospitalier Universitaire (CHU) Sainte-Justine Research Center, Montréal, QC, Canada10Department of Pathology and Clinical Laboratory Medicine, Centre Hospitalier Universitaire (CHU) Sainte-Justine, Montréal, QC, Canada11Department of Pediatrics, Centre Mère-Enfant Soleil du Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Québec, QC, Canada*V.L. and T.H.T. contributed equally to this work. https://doi.org/10.1200/PO.22.00200 First Page Full Text PDF Figures and Tables © 2022 by American Society of Clinical OncologyAUTHOR CONTRIBUTIONSConception and design: Antoine Gourmel, Nelson Piché, Valérie Larouche, Thai Hoa TranAdministrative support: Antoine GourmelProvision of study materials or patients: Antoine Gourmel, Alexandre Rouette, Naciba Benlimame, Ramy El-Jalbout, Mireille Dubé, Yves Théorêt, Valérie Larouche, Thai Hoa TranCollection and assembly of data: Antoine Gourmel, Alexandre Rouette, Naciba Benlimame, Yves Théorêt, Sébastien Labonté, Valérie Larouche, Thai Hoa TranData analysis and interpretation: Antoine Gourmel, Alexandre Rouette, Ramy El-Jalbout, Mireille Dubé, Yves Théorêt, Nelson Piché, Daniel Sinnett, Sonia Cellot, Dorothée Dal-Soglio, Valérie Larouche, Thai Hoa TranManuscript writing: All authorsFinal approval of manuscript: All authorsAccountable for all aspects of the work: All authorsAUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTERESTThe following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/po/author-center.Open Payments is a public database containing information reported by companies about payments made to US-licensed physicians (Open Payments).Thai Hoa TranConsulting or Advisory Role: Jazz Pharmaceuticals, Servier, BayerResearch Funding: ServierNo other potential conflicts of interest were reported.