Metabolic syndrome, radiographic osteoarthritis progression and chronic pain of the knee among men and women from the general population: the Rotterdam Study

Although a relationship between osteoarthritis and components of metabolic syndrome (MetS) has been suggested, most of the results have been cross-sectional. We, therefore, aimed to investigate the sex-specific longitudinal association of (components of) MetS with progression of radiographic osteoarthritis and chronic pain in the knee joints in a large prospective cohort.