已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Alterations in electroencephalographic functional connectivity in individuals with major depressive disorder: a resting-state electroencephalogram study

重性抑郁障碍 脑电图 静息状态功能磁共振成像 听力学 萧条(经济学) 心理学 评定量表 神经科学 精神科 阿尔法(金融) 功能连接 医学 内科学 临床心理学 认知 发展心理学 宏观经济学 心理测量学 经济 结构效度
作者
Yingtan Wang,Yu Chen,Yi Cui,Zhao Tong,Bin Wang,Yunxi Zheng,Yanping Ren,Sha Sha,Yumei Yan,Xixi Zhao,Ling Zhang,Gang Wang
出处
期刊:Frontiers in Neuroscience [Frontiers Media]
卷期号:18
标识
DOI:10.3389/fnins.2024.1412591
摘要

Background Major depressive disorder (MDD) is the leading cause of disability among all mental illnesses with increasing prevalence. The diagnosis of MDD is susceptible to interference by several factors, which has led to a trend of exploring objective biomarkers. Electroencephalography (EEG) is a non-invasive procedure that is being gradually applied to detect and diagnose MDD through some features such as functional connectivity (FC). Methods In this research, we analyzed the resting-state EEG of patients with MDD and healthy controls (HCs) in both eyes-open (EO) and eyes-closed (EC) conditions. The phase locking value (PLV) method was utilized to explore the connection and synchronization of neuronal activities spatiotemporally between different brain regions. We compared the PLV between participants with MDD and HCs in five frequency bands (theta, 4–8 Hz; alpha, 8–12 Hz; beta1, 12–16 Hz; beta2, 16–24 Hz; and beta3, 24–40 Hz) and further analyzed the correlation between the PLV of connections with significant differences and the severity of depression (via the scores of 17-item Hamilton Depression Rating Scale, HDRS-17). Results During the EO period, lower PLVs were found in the right temporal-left midline occipital cortex (RT-LMOC; theta, alpha, beta1, and beta2) and posterior parietal-right temporal cortex (PP-RT; beta1 and beta2) in the MDD group compared with the HC group, while PLVs were higher in the MDD group in LT-LMOC (beta2). During the EC period, for the MDD group, lower theta and beta (beta1, beta2, and beta3) PLVs were found in PP-RT, as well as lower theta, alpha, and beta (beta1, beta2, and beta3) PLVs in RT-LMOC. Additionally, in the left midline frontal cortex-right temporal cortex (LMFC-RT) and posterior parietal cortex-right temporal cortex (PP-RMOC), higher PLVs were observed in beta2. There were no significant correlations between PLVs and HDRS-17 scores when connections with significantly different PLVs (all p > 0.05) were checked. Conclusion Our study confirmed the presence of differences in FC between patients with MDD and healthy individuals. Lower PLVs in the connection of the right temporal-left occipital cortex were mostly observed, whereas an increase in PLVs was observed in patients with MDD in the connections of the left temporal with occipital lobe (EO), the circuits of the frontal-temporal lobe, and the parietal-occipital lobe. The trends in FC involved in this study were not correlated with the level of depression. Limitations The study was limited due to the lack of further analysis of confounding factors and follow-up data. Future studies with large-sampled and long-term designs are needed to further explore the distinguishable features of EEG FC in individuals with MDD.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
AFM发布了新的文献求助10
1秒前
2秒前
独特跳跳糖完成签到 ,获得积分10
2秒前
立军完成签到,获得积分10
5秒前
Sarah完成签到 ,获得积分10
6秒前
落晖完成签到 ,获得积分10
6秒前
Chi_bio发布了新的文献求助10
6秒前
xx1234567890发布了新的文献求助10
7秒前
张aa完成签到 ,获得积分10
7秒前
风鱼完成签到 ,获得积分10
8秒前
没有昵称完成签到 ,获得积分10
11秒前
三井库里发布了新的文献求助10
13秒前
17秒前
洛芷发布了新的文献求助10
20秒前
在水一方应助hugeng采纳,获得10
20秒前
Eliauk完成签到 ,获得积分10
22秒前
Jepsen完成签到 ,获得积分10
22秒前
22秒前
hhhi发布了新的文献求助10
27秒前
空里流霜不觉飞完成签到 ,获得积分10
28秒前
31秒前
hugeng完成签到,获得积分10
32秒前
noothinh完成签到,获得积分10
33秒前
Chi_bio完成签到,获得积分10
34秒前
lizigongzhu完成签到,获得积分10
34秒前
hugeng发布了新的文献求助10
35秒前
ding应助昏睡的南霜采纳,获得10
36秒前
ding应助曹大壮采纳,获得10
36秒前
yydragen应助黎乐荷采纳,获得30
36秒前
36秒前
Lucas应助废式脂肪采纳,获得10
37秒前
40秒前
lizigongzhu发布了新的文献求助10
43秒前
三井库里发布了新的文献求助10
45秒前
念初发布了新的文献求助10
46秒前
桐桐应助水之冬采纳,获得10
47秒前
48秒前
废式脂肪发布了新的文献求助10
51秒前
51秒前
今后应助hhhi采纳,获得10
53秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
Aktuelle Entwicklungen in der linguistischen Forschung 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989918
求助须知:如何正确求助?哪些是违规求助? 3532013
关于积分的说明 11255831
捐赠科研通 3270829
什么是DOI,文献DOI怎么找? 1805053
邀请新用户注册赠送积分活动 882233
科研通“疑难数据库(出版商)”最低求助积分说明 809216