组蛋白
生物
适应不良
赖氨酸
乙酰化
酶
细胞生物学
遗传学
生物化学
基因
氨基酸
作者
Shahnaz Ibrahim,Jayden Carter,Rushita A. Bagchi
出处
期刊:Physiology
[American Physiological Society]
日期:2024-10-29
标识
DOI:10.1152/physiol.00044.2024
摘要
Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl groups from key lysine residues on histone and non-histone proteins and thereby regulate gene transcription. They have been implicated in several biological processes in both healthy and pathologic settings. This review discusses the role of HDACs in multiple metabolically active tissues and highlights their contribution to the pathogenesis of tissue-specific maladaptation and diseases. We also summarize the current knowledge gaps and potential ways to address them in future studies.
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