Mechanism and performance of choline-based ionic liquids in enhancing nasal delivery of glucagon

并行传输 胆碱 化学 鼻腔给药 背景(考古学) 鼻粘膜 药理学 医学 生物化学 免疫学 生物 古生物学 磁导率
作者
Zirong Dong,Luyu Zhang,Guang‐Yue Li,Li Yang,Haisheng He,Yi Lü,Wei Wu,Jianping Qi
出处
期刊:Journal of Controlled Release [Elsevier]
卷期号:375: 812-828
标识
DOI:10.1016/j.jconrel.2024.09.035
摘要

Proteins and peptides have been increasingly developed as pharmaceuticals owing to their high potency and low side effects. However, their administration routes are confined to injections, such as intra-muscular and intra-venous injections, making patient compliance a challenge. Hence, non-injectable delivery systems are crucial to expanding the clinical use of proteins and peptides. In this context, two choline-based ionic liquids (ILs), namely, choline geranic acid ([Ch][Ger]) and choline citric acid ([Ch][Cit]), have been identified as promising agents for enhancing the permeation and prolonging the retention time of glucagon (GC) after intra-nasal administration. Notably, intra-nasal delivery of GC via ILs (GC/ILs) elicited rapid and smooth reversal of acute hypoglycaemia without leading to rebound hyperglycaemia in type 1 diabetic rats subjected to insulin induction. In addition, ILs could improve the transcellular transport of GC through electrostatic interaction. ILs could also transiently open inter-cellular tight junctions transiently to facilitate the paracellular transport of GC. Safety tests indicated that continuous intra-nasal delivery of ILs led to reversible changes, such as epithelial cell inflammation, goblet cell overgrowth, and impacts on the distribution of nasal cilia. However, these changes could be alleviated by the innate self-repair ability of mucosal epithelial cells. This study highlights the considerable potential of ILs for long-term nasal delivery of biomacromolecules.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
刚刚
哈哈哈完成签到,获得积分20
1秒前
摸猪头完成签到,获得积分20
1秒前
菜籽油发布了新的文献求助10
1秒前
你好完成签到,获得积分20
1秒前
2秒前
乾坤发布了新的文献求助10
2秒前
2秒前
2秒前
今后应助心灵美的宛丝采纳,获得10
2秒前
栗栗子完成签到,获得积分20
3秒前
Joefish完成签到,获得积分10
4秒前
时尚的青筠完成签到,获得积分10
4秒前
哈哈哈发布了新的文献求助10
5秒前
跳跃仙人掌应助Kabutack采纳,获得20
5秒前
5秒前
6秒前
煜琪发布了新的文献求助10
6秒前
6秒前
栗栗子发布了新的文献求助10
6秒前
Joefish发布了新的文献求助10
7秒前
8秒前
仲凯业发布了新的文献求助30
8秒前
你好发布了新的文献求助10
8秒前
花椒苦啊发布了新的文献求助10
8秒前
热心小松鼠给热心小松鼠的求助进行了留言
8秒前
pzw完成签到 ,获得积分10
9秒前
彪壮的小玉应助赵鹏辉采纳,获得30
9秒前
高大怀梦发布了新的文献求助10
9秒前
我啊发布了新的文献求助20
9秒前
ding应助章鱼采纳,获得10
9秒前
LabRat完成签到 ,获得积分10
9秒前
贪玩绮山完成签到,获得积分10
11秒前
11秒前
robust66完成签到,获得积分10
12秒前
12秒前
why发布了新的文献求助10
12秒前
牛牛123完成签到 ,获得积分10
15秒前
15秒前
高分求助中
Evolution 10000
Sustainability in Tides Chemistry 2800
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
Diagnostic immunohistochemistry : theranostic and genomic applications 6th Edition 500
Chen Hansheng: China’s Last Romantic Revolutionary 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3148410
求助须知:如何正确求助?哪些是违规求助? 2799502
关于积分的说明 7835226
捐赠科研通 2456813
什么是DOI,文献DOI怎么找? 1307424
科研通“疑难数据库(出版商)”最低求助积分说明 628189
版权声明 601655