作者
Guido Kobbe,Monika Brüggemann,Ben-Niklas Baermann,Laura Wiegand,Heiko Trautmann,Schayan Yousefian,Silvana Libertini,Hans D. Menssen,Harald J. Maier,Peter Ulrich,Jingbo Gao,Peter‐Martin Bruch,Nora Liebers,Aleksandar Radujkovic,Marc Seifert,Christina Schniederjohann,Nagarajan Paramasivam,Donnacha Fitzgerald,Maximilian Seidel,Iréne Esposito,Ulrich Germing,Ron‐Patrick Cadeddu,Kathrin Nachtkamp,Paul Jäger,Thomas Ulrych,Johannes C. Fischer,Jutta M. Rox,Frederik L. Giesel,Raphael Koch,Gerald Antoch,Jörg H. W. Distler,Sven G. Meuth,Malte Jacobsen,Daniel Hübschmann,Junyan Lu,Ingram Iaccarino,Simon Haas,Frédérik Damm,Sascha Dietrich
摘要
The development of a fatal, clonal, autonomously proliferating CD4-CD8- chimeric antigen receptor (CAR)+ peripheral T-cell lymphoma (PTCL) occurred 1 month after a patient received treatment with tisagenlecleucel for relapsed primary central nervous system lymphoma. The PTCL had a clonal T-cell receptor rearrangement, which was already detectable in the apheresis product for CAR T-cell manufacturing and 7 months earlier for autologous transplantation. Somatic
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