淋巴瘤
汽车T细胞治疗
CD19
医学
侵袭性淋巴瘤
肿瘤科
嵌合抗原受体
T细胞
免疫学
抗原
美罗华
免疫系统
作者
Guido Kobbe,Monika Brüggemann,Ben-Niklas Baermann,Laura Wiegand,Heiko Trautmann,Schayan Yousefian,Silvana Libertini,Hans D. Menssen,Harald J. Maier,Peter Ulrich,Jingbo Gao,Peter‐Martin Bruch,Nora Liebers,Aleksandar Radujkovic,Marc Seifert,Christina Schniederjohann,Nagarajan Paramasivam,Donnacha Fitzgerald,Maximilian Seidel,Iréne Esposito
标识
DOI：10.1056/nejmoa2402730
摘要
The development of a fatal, clonal, autonomously proliferating CD4-CD8- chimeric antigen receptor (CAR)+ peripheral T-cell lymphoma (PTCL) occurred 1 month after a patient received treatment with tisagenlecleucel for relapsed primary central nervous system lymphoma. The PTCL had a clonal T-cell receptor rearrangement, which was already detectable in the apheresis product for CAR T-cell manufacturing and 7 months earlier for autologous transplantation. Somatic
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