异位骨化
作用机理
机制(生物学)
骨化
医学
药理学
对接(动物)
化学
外科
生物化学
物理
体外
量子力学
护理部
作者
Yi Du,Zhenjie Wang,Xiaolin Cai,Jinfeng Zhu,Y Wang,Jinjin Wang,Peiying Huang,Wenhua Ke,Ziyi Luo,Yi Liu,Chun Yang
出处
期刊:Current Drug Therapy
[Bentham Science]
日期:2024-09-27
卷期号:19
标识
DOI:10.2174/0115748855341056240911101658
摘要
Background: Danxiong Huoxue tablets have been used clinically to prevent and treat Heterotopic Ossification (HO) after total hip arthroplasty, but its therapeutic mechanism is not clear. background: Danxiong Huoxue Tablets has been used clinically to prevent and treat heterotopic ossification (HO) after total hip arthroplasty, but its therapeutic mechanism is not clear. Objectives: This study investigated the potential mechanism of action of Danxiong Huoxue tablets against HO using network pharmacology and molecular docking methods. Methods: The TCMID and SymMap databases and the existing literature were used to screen the active ingredients and targets of Danxiong Huoxue tablets, and the targets of heterotopic ossification were obtained from Gene Cards, DisGeNET, and PharmGkb databases. The PPI network diagram was constructed using the String database and Cytoscape 3.9.1 software. Finally, the core targets were analyzed by GO and KEGG enrichment and validated by molecular docking. Results: A total of 39 active ingredients and 328 corresponding targets of Danxiong Huoxue tablets were identified, which were enriched in signaling pathways, such as PI3K/Akt and MAPK. Molecular docking verified that there was good binding activity between the core targets and the corresponding components. Conclusion: Danxiong Huoxue tablets may prevent and treat HO by acting on key targets, such as SRC, AKT1, JUN, and TNF, and regulating the PI3K/Akt signaling pathway and MAPK signaling pathway.
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