Abstract Transition element‐based materials hold advantageous morphological and physicochemical attributes due to their remarkably varying valence states and highly stable metal ions. Amidst them, manganese dioxide (MnO 2 ) has gained massive interest from researchers due to its ease of fabricating diverse nanostructures with unique morphological, physicochemical, and optoelectronic features. In addition, MnO 2 has displayed exciting potential as biomedicine owing to its good biocompatibility, large surface area, and ultrathin thickness. This allows its participation in intracellular biochemical reactions, causing alteration of the internal microenvironment. To domain these exceptional features and enhance biocompatibility, several MnO 2 ‐based nanocomposites have been devised by researchers. In this review article, we attempt to provide a comprehensive assessment of various MnO 2 ‐based nanoparticle synthesis and its corresponding antibacterial activity explored over the past decade.