卡比多巴
左旋多巴
医学
剂型
立即释放
药理学
药品
药店
重症监护医学
内科学
疾病
家庭医学
帕金森病
作者
Evelina Maines,Giorgio Temporin,Michela Fedrizzi,Alessandra Pasqualini,Lorenzo Junior Masnata,Annalisa Campomori,Alessandro Iodice,Giovanni Piccoli,Massimo Soffiati,Roberto Franceschi,Silvana Anna Maria Urru
标识
DOI:10.1016/j.ejpb.2024.114429
摘要
sepiapterine reductase deficiency (SRD) is a rare levodopa (L-dopa)-responsive disorder treated with a combination therapy of controlled-release L-dopa and carbidopa. The currently available formulation of controlled-release carbidopa/L-dopa does not entirely meet the requirements for the long-term therapy in pediatric patients. In fact, administration of a manufactured tablet at a dose intended for adults necessitates its adjustment to the child's needs, as the splitting of the tablet into smaller portions or its dilution in water. It's essential to emphasize that tablets must not be crushed, as this can compromise the controlled-release mechanism and affect the efficacy of the medication. At the moment, commercial liquid formulations are not available. Given these limitations, in house drug preparation in hospitals and community pharmacies is a valid option to ensure the proper therapeutic management of these patients.
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