Comprehensive monitoring and prioritizing for contaminants of emerging concern in the Upper Yangtze River, China: An integrated approach

Contaminants of emerging concern (CECs) in aquatic environments can adversely impact ecosystems and human health even at low concentrations. This study assessed the risk of 162 CECs, including neonicotinoid pesticides, triazine pesticides, carbamate pesticides, psychoactive substances, organophosphate esters, antidepressants, per- and polyfluoroalkyl substances, and antibiotics in 10 drinking water sources and two tributaries (Jialing and Wujiang Rivers) of the Upper Yangtze River in Chongqing, China. Target screening detected 156 CECs at 0.01-2218.2 ng/L, while suspect screening via LC-QTOF-MS identified 64 CECs, with 13 pesticides, 29 pharmaceuticals and personal care products, and 2 industrial chemicals reported for the first time in the Yangtze River Basin. Risk quotient-based ecological risk assessment revealed that 48 CECs posed medium to high risks (RQ > 0.1) to aquatic life, with antibiotics (n = 20) as the main contributors. Non-carcinogenic risks were below negligible levels, but carcinogenic risks from neonicotinoids, triazines, antidepressants, and antibiotics were concerning. A multi-criteria prioritization approach integrating occurrence, physico-chemical properties, and toxicological data ranked 26 CECs as high priority. This study underscores the importance of comprehensive CEC screening in rivers and provides insights for future monitoring and management strategies.