Association between the anion-gap and 28-day mortality in critically ill adult patients with sepsis: A retrospective cohort study

医学 四分位间距 感染性休克 回顾性队列研究 败血症 重症监护室 优势比 内科学 重症监护 队列 死亡率 混淆 队列研究 四分位数 重症监护医学 置信区间
作者
Zeying Lou,Fanghua Zeng,Wenbao Huang,Xiaoli Li,Kang Zou,Huasheng Zhou
出处
期刊:Medicine [Wolters Kluwer]
卷期号:103 (30): e39029-e39029
标识
DOI:10.1097/md.0000000000039029
摘要

Metabolic acidosis is usually associated with the severity of the condition of patients with sepsis or septic shock. Serum anion gap (AG) is one of the indicators of response metabolism. This study was performed to investigate whether the initial serum AG is associated with the 28-day mortality in critically ill adult patients with sepsis. This retrospective cohort study, a total of 15,047 patients with confirmed Sepsis disease from 2008 to 2019 from the Medical Information Mart for Intensive Care IV (MIMIC-IV) v1.0 database. The MIMIC-IV database is a comprehensive, de-identified clinical dataset originating from the Beth Israel Deaconess Medical Center in Boston, it includes extensive data on intensive care unit (ICU) patients, such as vital signs, lab results, and medication orders, spanning multiple years, accessible to researchers through an application process. AG can be obtained by direct extraction in the MIMIC-IV database (itemid = 50,868 from the laboratory events table of mimic_hosp), inclusion of AG values for the first test on first day of ICU admission. The patients were grouped into quartiles according to the AG interquartile range. The primary outcome was the 28-day mortality. Multiple logistic regression analysis was used to calculate the odds ratio (OR), while accounting for potential confounders, and the robustness of the results were evaluated in subgroup analyses. Among the 15,047 patients included in this study, the average age was 65.9 ± 16.0 years, 42.5% were female, 66.1% were Caucasian, and the 28-day mortality rate was 17.9% (2686/15,047). Multiple logistic regression analysis revealed the 28-day mortality in every increase of AG (per SD mEq/L), there is an associated 1.2 times (OR 1.2, 95% CI 1.12-1.29, P < .001) increase. Increased 28-day mortality (OR 1.53, 95% confidence interval 1.29-1.81, P < .001) in the group with the AG (15-18 mEq/L), and (OR 1.69, 95% confidence interval 1.4-2.04, P < .001) in the group with the highest AG (≥18 mEq/L), AG (<12 mEq/L) as a reference group, in the fully adjusted model. In adult patients with sepsis, the early AG at the time of ICU admission is an independent risk factor for prognosis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
yue完成签到,获得积分10
4秒前
淼队完成签到,获得积分10
5秒前
5秒前
落叶解三秋完成签到,获得积分10
6秒前
Crystal完成签到 ,获得积分10
9秒前
小小酥完成签到,获得积分10
9秒前
等待蚂蚁完成签到 ,获得积分10
10秒前
zgt01发布了新的文献求助10
10秒前
心心完成签到 ,获得积分10
11秒前
123完成签到,获得积分10
12秒前
温超完成签到,获得积分10
12秒前
量子星尘发布了新的文献求助10
12秒前
13秒前
14秒前
Menta1y完成签到,获得积分10
14秒前
czzlancer完成签到,获得积分10
15秒前
汶溢完成签到,获得积分10
15秒前
xsss完成签到,获得积分10
16秒前
TAN完成签到,获得积分10
16秒前
通通通发布了新的文献求助10
17秒前
liudw完成签到,获得积分10
17秒前
丹丹子完成签到 ,获得积分10
18秒前
时光完成签到,获得积分10
18秒前
19秒前
充电宝应助vsvsgo采纳,获得10
21秒前
123完成签到 ,获得积分10
23秒前
Ammr完成签到 ,获得积分10
23秒前
无限的依波完成签到,获得积分10
23秒前
姽婳wy发布了新的文献求助10
24秒前
lemon完成签到,获得积分10
24秒前
传奇3应助duckspy采纳,获得30
25秒前
陈木木完成签到,获得积分10
26秒前
可可西里完成签到,获得积分10
27秒前
奋斗蜗牛完成签到,获得积分10
27秒前
CipherSage应助眼睛大的擎苍采纳,获得10
27秒前
打打应助小小酥采纳,获得10
28秒前
fox完成签到 ,获得积分10
28秒前
僦是卜够完成签到 ,获得积分10
29秒前
小马甲应助嘉梦采纳,获得10
32秒前
qiqi完成签到,获得积分10
33秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038235
求助须知:如何正确求助?哪些是违规求助? 3575992
关于积分的说明 11374009
捐赠科研通 3305760
什么是DOI,文献DOI怎么找? 1819276
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022