抗坏血酸
电化学
原位
材料科学
牛血清白蛋白
微电极
碳纳米管
Nafion公司
电极
化学工程
化学
纳米技术
色谱法
有机化学
食品科学
物理化学
工程类
作者
Zhiyuan Zheng,Ningxuan Liu,Jiajia Lu,Xiang Zhou,Zibin Song,Yida An,Ling Lu,Peng Zhao,Jia Tao
出处
期刊:Small
[Wiley]
日期:2024-10-13
标识
DOI:10.1002/smll.202407101
摘要
Abstract Accurate determination of cerebral ascorbic acid (AA) is crucial for understanding ischemic stroke (IS) related pathological events. Carbon fiber microelectrodes (CFEs) have proven to be robust tools with high sensitivity toward AA, however, they face ongoing challenges for in situ measurement due to the non‐specific adsorption of proteins in brain tissue. In this study, the hydrogen‐bonded organic framework PFC‐71 is synthesized and modified on CFEs through π‐π stacking interactions with carboxylated carbon nanotubes (CNT ‐COOH ). It is found that the gating effect and hydrophilicity of PFC‐71 provided the CFE with excellent antibiofouling properties. As a result, AA exhibited a low oxidation potential of −30 mV on the CFE/CNT ‐COOH /PFC‐71, even in the presence of 20 mg mL −1 bovine serum albumin. Given the structural advantages of CFE/CNT ‐COOH /PFC‐71, a ratiometric electrochemical strategy for AA is established, enabling the in situ assay of cerebral AA in a middle cerebral artery occlusion (MCAO) model with high accuracy and stability.
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