小胶质细胞
血脑屏障
肠道菌群
免疫系统
肠-脑轴
冲程(发动机)
脑功能
功能(生物学)
免疫学
神经科学
炎症
生物
细胞生物学
中枢神经系统
机械工程
工程类
作者
Khiany Mathias,Richard Simon Machado,Solange Stork,Carla Damasio Martins,David dos Santos,Fabrício Weinheimer Lippert,Josiane Somariva Prophiro,Fabrícia Petronilho
出处
期刊:Life Sciences
[Elsevier]
日期:2024-08-13
卷期号:354: 122979-122979
标识
DOI:10.1016/j.lfs.2024.122979
摘要
Stroke is the second most common cause of death and one of the most common causes of disability worldwide. The intestine is home to several microorganisms that fulfill essential functions for the natural and physiological functioning of the human body. There is an interaction between the central nervous system (CNS) and the gastrointestinal system that enables bidirectional communication between them, the so-called gut-brain axis. Based on the gut-brain axis, there is evidence of a link between the gut microbiota and the regulation of microglial functions through glial activation. This interaction is partly due to the immunological properties of the microbiota and its connection with the CNS, such that metabolites produced by the microbiota can cross the gut barrier, enter the bloodstream and reach the CNS and significantly affect microglia, astrocytes and other cells of the immune system. Studies addressing the effects of short-chain fatty acids (SCFAs) on glial function and the BBB in ischemic stroke are still scarce. Therefore, this review aims to stimulate the investigation of these associations, as well as to generate new studies on this topic that can clarify the role of SCFAs after stroke in a more robust manner.
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