对映选择合成
共价键
膜
纳米技术
化学
材料科学
有机化学
催化作用
生物化学
作者
Chen‐Yan Zheng,Hai‐Long Qian,Cheng Yang,Xiu‐Ping Yan
标识
DOI:10.1002/smtd.202401120
摘要
Abstract Nanochannel membranes are promising materials for enantioselective sensing. However, it is difficult to make a compromise between the selectivity and permeability in traditional nanochannel membranes. Therefore, new types of nanochannel membranes with high enantioselectivity and excellent permeability should be explored for chiral analysis. Here, asymmetric catalysis strategy is reported for interfacial polymerization synthesis of chiral covalent‐organic framework (cCOF) nanochannel membrane for enantioselective sensing. Chiral phenylethylamine ( S / R ‐PEA) and 2,4,6‐triformylphloroglucinol (TP) are used to prepare chiral TP monomer. 4,4′,4″‐triaminotriphenylamine (TAPA) is then condensed with chiral TP to obtain cCOF nanochannel membrane via a C═N Schiff‐base reaction. The molar ratio of TP to S/R ‐PEA is adjusted so that S/R ‐PEA is bound to the aldehyde only or both the aldehyde and hydroxyl groups on TP to obtain chiral‐induced COF (cCOF‐1) or both chiral‐induced and modified COF (cCOF‐2) nanochannel membrane, respectively. The prepared cCOF‐2 nanochannel membrane showed two times more selectivity for limonene enantiomers than cCOF‐1 nanochannel membrane. Furthermore, cCOF‐2 nanochannel platform exhibited excellent sensing performance for other chiral molecules such as limonene, propanediol, methylbutyric acid, ibuprofen, and naproxen (limits of detection of 19–42 ng L −1 , enantiomer excess of 63.6–86.3%). This work provides a promising way to develop cCOF‐based nanochannel enantioselective sensor.
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