Effect of Adding Electroacupuncture to Standard Triple Antiemetic Therapy on Chemotherapy-Induced Nausea and Vomiting: A Randomized Controlled Clinical Trial

医学 止吐药 化疗引起恶心呕吐 呕吐 恶心 电针 随机对照试验 化疗 麻醉 针灸科 内科学 替代医学 病理
作者
Guoshuang Shen,Dengfeng Ren,Fuxing Zhao,Miaozhou Wang,Zhen Liu,Xiumei Feng,Yingjian He,Xinlan Liu,Xiaoling Ling,Yi Zhao,Feixue Song,Jiyan Ma,Enxi Li,Tong She,Zhilin Liu,Zitao Li,Shifen Huang,Yongzhi Chen,Jingru Yang,Xuan Li
出处
期刊:Journal of Clinical Oncology [Lippincott Williams & Wilkins]
被引量:2
标识
DOI:10.1200/jco.24.00099
摘要

PURPOSE We aim to determine the effectiveness of adding electroacupuncture to standard triple antiemetic therapy for treating chemotherapy-induced nausea and vomiting (CINV). METHODS From March 2022 to December 2023, a randomized, blind, sham-controlled trial conducted across six Chinese hospitals investigated patients with breast cancer undergoing highly emetogenic chemotherapy (HEC). Patients were randomly assigned to either true electroacupuncture (n = 120) or sham electroacupuncture (n = 119) groups, with both groups receiving standard triple antiemetic therapy. The primary end point was the proportion of complete protection (no vomiting, no need for rescue treatment, and no significant nausea, as evaluated using the visual analog scale [VAS]) within 120 hours after receiving HEC. RESULTS Among 239 randomly assigned patients, 235 (98.3%) completed the trial. In the full analysis set, compared with the sham electroacupuncture group, the true electroacupuncture group demonstrated a significant increase in the complete protection rate from 34.5% to 52.9% ( P = .004). Additionally, true electroacupuncture also showed enhanced total control (4.3% v 13.4%; P = .014), no significant nausea (37.9% v 58.8%; P = .001), no nausea (4.3% v 13.4%; P = .014), and nausea VAS score = 0 mm (4.3% v 12.6%; P = .023). However, the occurrence of no vomiting in the overall stage was similar (76.7% v 73.9%; P = .622) in both groups. Post hoc exploratory analysis showed a significantly higher rate of complete protection during the delayed stage in the true electroacupuncture group compared with the sham electroacupuncture group, with no significant difference observed during the acute stage. CONCLUSION Adding true electroacupuncture to standard triple antiemetic therapy significantly enhances the efficacy of CINV treatment in patients with breast cancer receiving HEC.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
yizhiGao应助科研通管家采纳,获得10
刚刚
NexusExplorer应助科研通管家采纳,获得10
刚刚
Orange应助科研通管家采纳,获得10
刚刚
脑洞疼应助科研通管家采纳,获得10
刚刚
深情安青应助科研通管家采纳,获得10
刚刚
1秒前
1秒前
cherlie应助科研通管家采纳,获得10
1秒前
上官若男应助科研通管家采纳,获得10
1秒前
1秒前
MEDwhy完成签到,获得积分10
2秒前
2秒前
雨声完成签到,获得积分10
3秒前
DueR发布了新的文献求助10
3秒前
Liufgui应助YJ888采纳,获得10
3秒前
4秒前
6秒前
7秒前
学术蝗虫发布了新的文献求助10
8秒前
好好好完成签到,获得积分10
8秒前
王某发布了新的文献求助30
8秒前
8秒前
张兔子关注了科研通微信公众号
13秒前
难过冷玉发布了新的文献求助10
13秒前
逸晨发布了新的文献求助10
13秒前
16秒前
16秒前
水蜜桃幽灵完成签到,获得积分20
18秒前
难过冷玉完成签到,获得积分10
19秒前
a雪橙发布了新的文献求助10
20秒前
20秒前
Hina发布了新的文献求助30
20秒前
eueurhj完成签到,获得积分10
22秒前
多情邑发布了新的文献求助10
23秒前
上官若男应助逸晨采纳,获得10
23秒前
Akim应助阿童木采纳,获得10
23秒前
好好好发布了新的文献求助10
24秒前
24秒前
郑伟李完成签到,获得积分10
25秒前
25秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989550
求助须知:如何正确求助?哪些是违规求助? 3531774
关于积分的说明 11254747
捐赠科研通 3270278
什么是DOI,文献DOI怎么找? 1804966
邀请新用户注册赠送积分活动 882125
科研通“疑难数据库(出版商)”最低求助积分说明 809176