Effector Functions of Dendritic Cells in Cancer: Role of Cytotoxicity and Growth Inhibition

效应器 细胞毒性 细胞生物学 癌症研究 癌细胞 化学 癌症 生物 体外 生物化学 遗传学
作者
Pratima Chaudhary,Prateek Srivastava,Partha Pratim Manna
出处
期刊:Frontiers in bioscience [Bioscience Research Institute Pte. Ltd.]
卷期号:29 (8): 293-293
标识
DOI:10.31083/j.fbl2908293
摘要

The tumor microenvironment plays a critical role in modulating immune responses associated with tumorigenesis, tumor progression, and metastasis. Dendritic cells (DC) play a key role in preventing and progression of metastatic neoplasia by driving and restoring dysfunctional immune systems and obliterating immunosuppression, thus obstructing tumor evasion. In this review, we will discuss the functions of tumor-infiltrating DC in anti-tumor resistance, prevention of tumor recurrence, and immunosuppression. We will also describe DC metabolism, differentiation, and plasticity, which are essential for its function. Cancers like Lymphomas may be able to corrupt immune surveillance by reducing natural killer cell numbers. Thus, interactions between lymphoma and DC with reference to cytotoxicity may be an important event, likely to be mediated via activation with interferon-γ (IFN-γ) and Toll like receptors (TLR) ligands. Mechanisms of DC-mediated cytotoxicity and the role of apoptosis and death receptors, including the role played by nitric oxide, etc., are of immense significance. We will also look into the molecular mechanisms in the tumor microenvironment, reduced drug sensitivity, and tumor relapse, as well as methods for combating drug resistance and focusing on immunosuppressive tumor networks. We will address how DC mediated cytotoxicity in combination with drugs affects tumor growth and expansion in relation to checkpoint inhibitors and regulatory T cells. Innovative approaches for therapeutic modulation of this immunosuppressive adoptive DC immunotherapy will be highlighted, which is necessary for future personalized therapeutic applications.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
长情雪兰完成签到,获得积分10
2秒前
cocolu举报susu求助涉嫌违规
3秒前
范旭东发布了新的文献求助10
3秒前
深情安青应助孙总采纳,获得10
4秒前
朝阳发布了新的文献求助10
5秒前
自然的南露完成签到 ,获得积分10
5秒前
大个应助Helen采纳,获得10
7秒前
7秒前
kkk发布了新的文献求助10
7秒前
7秒前
明晨完成签到 ,获得积分10
9秒前
10秒前
HaishanGuan发布了新的文献求助10
10秒前
10秒前
wangdao完成签到,获得积分10
10秒前
科研小白应助范旭东采纳,获得10
11秒前
11秒前
liu发布了新的文献求助10
11秒前
cjdsb完成签到,获得积分10
13秒前
yyy完成签到,获得积分10
13秒前
乐乐应助奥一奥采纳,获得10
14秒前
朝阳完成签到,获得积分10
14秒前
14秒前
14秒前
16秒前
双勾玉发布了新的文献求助10
18秒前
NexusExplorer应助沉静的煎蛋采纳,获得30
18秒前
孤独的青文完成签到 ,获得积分10
18秒前
灵巧秋蝶发布了新的文献求助10
18秒前
小馒头完成签到,获得积分10
19秒前
斯文败类应助科研通管家采纳,获得10
19秒前
19秒前
小蘑菇应助科研通管家采纳,获得10
19秒前
英姑应助科研通管家采纳,获得10
19秒前
英姑应助科研通管家采纳,获得10
19秒前
Akim应助科研通管家采纳,获得10
19秒前
如初应助科研通管家采纳,获得10
19秒前
明理采珊发布了新的文献求助10
21秒前
开放初曼完成签到,获得积分10
21秒前
高分求助中
Licensing Deals in Pharmaceuticals 2019-2024 3000
Effect of reactor temperature on FCC yield 2000
Very-high-order BVD Schemes Using β-variable THINC Method 1020
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
Near Infrared Spectra of Origin-defined and Real-world Textiles (NIR-SORT): A spectroscopic and materials characterization dataset for known provenance and post-consumer fabrics 610
Mission to Mao: Us Intelligence and the Chinese Communists in World War II 600
Promoting women's entrepreneurship in developing countries: the case of the world's largest women-owned community-based enterprise 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3306326
求助须知:如何正确求助?哪些是违规求助? 2940151
关于积分的说明 8495886
捐赠科研通 2614382
什么是DOI,文献DOI怎么找? 1428121
科研通“疑难数据库(出版商)”最低求助积分说明 663291
邀请新用户注册赠送积分活动 648135