Simultaneously Predicting Pharmacokinetics of Loratadine and Desloratadine in Children Using a Whole‐Body Physiologically Based Pharmacokinetic Model

氯雷他定 地氯雷他定 基于生理学的药代动力学模型 药代动力学 药理学 医学
作者
Tianlei Liu,Ruijing Mu,Xiaodong Liu
出处
期刊:The Journal of Clinical Pharmacology [Wiley]
标识
DOI:10.1002/jcph.6120
摘要

Abstract Loratadine is metabolized to desloratadine. Both of them have been used for allergy treatment in children. Anatomical, physiological, and biological parameters of children and clearance of drugs vary with age. We aimed to develop a whole‐body physiologically based pharmacokinetic (PBPK) model to simultaneously predict the pharmacokinetics of loratadine and desloratadine in children. Following validation using 11 adult data sets, the developed PBPK model was extrapolated to children. Plasma concentrations following oral loratadine or desloratadine to children of different ages were simulated and compared with six children data sets. After scaling anatomy/physiology, protein binding, and clearance, pharmacokinetics of the two drugs in pediatric populations were satisfactorily predicted. Most of the observed concentrations fell within the 5th‐95th percentile range of the simulations in 1000 virtual children. The predicted area under the concentration‐time curve (AUC) and C max fell within 0.5‐2.0‐fold range of the observations. Oral doses of loratadine or desloratadine for children of different ages were simulated based on similar AUCs following 10 mg of loratadine or 5 mg of desloratadine for adults. Pediatric PBPK model was successfully developed to simultaneously predict plasma concentrations of loratadine and desloratadine in children of all ages. The developed pediatric PBPK model may also be applied to optimize pediatric dosage.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
1秒前
小猫多鱼完成签到,获得积分10
1秒前
科目三应助Sandra采纳,获得10
2秒前
xuanye完成签到,获得积分10
4秒前
liberty发布了新的文献求助10
4秒前
4秒前
叫个啥嘞发布了新的文献求助10
5秒前
拓跋涵易发布了新的文献求助10
5秒前
YY发布了新的文献求助30
8秒前
芓菡完成签到,获得积分10
8秒前
叫个啥嘞完成签到,获得积分10
11秒前
11秒前
负责惊蛰发布了新的文献求助10
12秒前
Sandra完成签到,获得积分20
14秒前
李爱国应助默默的甜瓜采纳,获得10
14秒前
852应助hsy采纳,获得10
15秒前
16秒前
可爱奇异果完成签到 ,获得积分10
17秒前
治愈小羊发布了新的文献求助10
17秒前
在水一方应助玩家采纳,获得10
19秒前
YY完成签到 ,获得积分20
19秒前
22秒前
23秒前
LJF完成签到,获得积分10
25秒前
26秒前
负责惊蛰完成签到,获得积分10
26秒前
27秒前
宋雪芹发布了新的文献求助10
28秒前
nqterysc完成签到,获得积分10
28秒前
28秒前
cuizaixu发布了新的文献求助10
29秒前
30秒前
31秒前
桐桐应助拓跋涵易采纳,获得10
31秒前
呆萌水壶完成签到 ,获得积分10
32秒前
32秒前
32秒前
mizih发布了新的文献求助20
33秒前
半城烟火完成签到 ,获得积分10
33秒前
高分求助中
Evolution 10000
Sustainability in Tides Chemistry 2800
юрские динозавры восточного забайкалья 800
Diagnostic immunohistochemistry : theranostic and genomic applications 6th Edition 500
Chen Hansheng: China’s Last Romantic Revolutionary 500
China's Relations With Japan 1945-83: The Role of Liao Chengzhi 400
Classics in Total Synthesis IV 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3150268
求助须知:如何正确求助?哪些是违规求助? 2801406
关于积分的说明 7844576
捐赠科研通 2458893
什么是DOI,文献DOI怎么找? 1308793
科研通“疑难数据库(出版商)”最低求助积分说明 628566
版权声明 601721