红细胞生成
生物
造血
细胞生物学
背景(考古学)
重编程
细胞分化
干细胞
代谢途径
血细胞
代谢物
造血干细胞
祖细胞
下调和上调
细胞命运测定
细胞
生物化学
新陈代谢
遗传学
转录因子
基因
医学
古生物学
内科学
贫血
作者
Axel Joly,Anne-Kathrin Schott,Ira Phadke,Pedro González‐Menéndez,Sandrina Kinet,Naomi Taylor
出处
期刊:Physiology
[American Physiological Society]
日期:2024-09-03
标识
DOI:10.1152/physiol.00035.2024
摘要
Hematopoietic stem cells (HSCs) possess the capacity for self-renewal and the sustained production of all mature blood cell lineages. It has been well established that a metabolic rewiring controls the switch of HSCs from a self-renewal state to a more differentiated state but it is only recently that we have appreciated the importance of metabolic pathways in regulating the commitment of progenitors to distinct hematopoietic lineages. In the context of erythroid differentiation, an extensive network of metabolites - including amino acids, sugars, nucleotides, fatty acids, vitamins, and iron - is required for red blood cell (RBC) maturation. In this review, we will highlight the multi-faceted roles via which metabolites regulate physiological erythropoiesis as well as the effects of metabolic perturbations on erythroid lineage commitment and differentiation. Of note, the erythroid differentiation process is associated with an exceptional breadth of SLC metabolite transporter upregulation. Finally, we will discuss how recent research, revealing the critical impact of metabolic reprogramming in diseases of disordered and ineffective erythropoiesis, has created opportunities for the development of novel metabolic-centered therapeutic strategies.
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