亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Neighborhood Stressors and Epigenetic Age Acceleration among Older Americans

压力源 答辩人 人口学 健康与退休研究 老年学 心理学 社会经济地位 民族 医学 临床心理学 环境卫生 人口 社会学 政治学 人类学 法学
作者
Eun Young Choi,Jennifer Ailshire
出处
期刊:The Journals of Gerontology: Series B [Oxford University Press]
卷期号:79 (12)
标识
DOI:10.1093/geronb/gbae176
摘要

Abstract Objectives Exposure to stressful neighborhood environments is a well-established risk factor for health deterioration and premature death. However, the biological underpinnings are not fully understood. Epigenetic aging may function as a key molecular pathway to adverse health outcomes among residents of high-stress neighborhoods. This study examines the associations between neighborhood social stressors (socioeconomic deprivation, observed and perceived disorder, and low social cohesion) and epigenetic age (DunedinPACE and Principal component adjusted [PC] PCHorvath, PCHannum, PCPhenoAge, PCGrimAge). Further, we identify subpopulations most vulnerable to neighborhood stressors. Methods Respondent data are from the 2016 Health and Retirement Study (HRS) DNA methylation subsample. Neighborhood data come from respondent reports (2014/2016) and the census (2012–2016 ACS). The analytic sample included 3,146 adults ages 56 and older (mean age = 68.8), of whom 54.9% were women and 19.3% were non-White. Results In multilevel regression models adjusting for sociodemographic covariates, all neighborhood stressors were associated with faster DunedinPACE (B = 0.008 to 0.017). Neighborhood deprivation, perceived disorder, and low cohesion were associated with PCPhenoAge (B = 0.27 to 0.40) or PCGrimAge acceleration (B = 0.23). Health behaviors explained these associations to some degree. However, no significant associations were found with PCHorvath and PCHannum. In interaction analyses, adverse associations with deprivation, observed disorder, and low cohesion were more pronounced for women. No consistent interactions were found for race/ethnic and education groups. Discussion Our findings indicate that neighborhood stressors can accelerate epigenetic aging, with older women particularly vulnerable to their effects. These findings provide insights into the biological foundations of health disparities rooted in neighborhood environments.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
13秒前
小叶子完成签到 ,获得积分10
13秒前
Liufgui应助徐悦月采纳,获得10
15秒前
19秒前
Dave完成签到,获得积分10
34秒前
FashionBoy应助Dave采纳,获得10
37秒前
38秒前
39秒前
42秒前
顾矜应助Emon采纳,获得10
56秒前
1分钟前
1分钟前
芝麻完成签到,获得积分10
1分钟前
1分钟前
Dave发布了新的文献求助10
1分钟前
大模型应助芝麻采纳,获得10
1分钟前
1分钟前
jjjjj发布了新的文献求助10
1分钟前
Liufgui应助花凉采纳,获得20
1分钟前
biubiubiu发布了新的文献求助10
2分钟前
万能图书馆应助章鱼采纳,获得10
2分钟前
jjjjj完成签到,获得积分20
2分钟前
2分钟前
章鱼发布了新的文献求助10
2分钟前
牛八先生完成签到,获得积分10
2分钟前
2分钟前
孙燕应助jjjjj采纳,获得30
2分钟前
Liufgui应助花凉采纳,获得20
2分钟前
Ava关闭了Ava文献求助
2分钟前
科研通AI2S应助liudy采纳,获得10
2分钟前
科研通AI2S应助sljzhangbiao11采纳,获得10
2分钟前
2分钟前
徐悦月发布了新的文献求助10
2分钟前
三笠发布了新的文献求助10
2分钟前
小刘完成签到,获得积分10
3分钟前
3分钟前
三笠完成签到,获得积分10
3分钟前
传奇3应助Liiiiiiiiii采纳,获得10
3分钟前
gt完成签到 ,获得积分10
3分钟前
3分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990045
求助须知:如何正确求助?哪些是违规求助? 3532108
关于积分的说明 11256334
捐赠科研通 3270943
什么是DOI,文献DOI怎么找? 1805146
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809228