葡聚糖
酵母
肠道菌群
结肠炎
化学
生物化学
硫酸盐
食品科学
钠
葡萄聚糖
生物
免疫学
有机化学
作者
S. J. Li,Huihui Peng,Yuning Sun,Jiali Yang,Juan Wang,Fuqing Bai,Chuanyi Peng,Shuzhen Fang,Huimei Cai,Guijie Chen
标识
DOI:10.1016/j.ijbiomac.2024.135846
摘要
Yeast β-glucan intervention offers a promising strategy for managing colitis; however, the mechanisms remain unknown. In the present work, the protective effects of yeast β-glucan on DSS-induced colitis in mice was evaluated, focusing on its interaction with gut microbiota. The result showed yeast β-glucan significantly alleviated colitis symptoms, evidenced by reduced weight loss, lower disease activity index (DAI) scores, and minimized intestinal damage. It enhanced intestinal barrier integrity via upregulation of tight junction proteins, suppressed lipopolysaccharide (LPS) release, and decreased pro-inflammatory cytokines production. Additionally, yeast β-glucan boosted short-chain fatty acids (SCFAs) production, and activated their receptors, increased the relative abundances of beneficial microbes like Lactobacillus and Lachnospiraceae_UCG-006. Transcriptomic analyses suggest that yeast β-glucan mitigates inflammation by downregulating gene expression related to IL-17 pathway. Our findings highlight potential of yeast β-glucan as a therapeutic agent for colitis through modulation of gut microbiota and inflammatory responses.
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