化学
叠氮化钠
酰胺
叠氮化物
柯蒂斯重排
酰氯
尿素
亲核酰基取代反应
钠
有机化学
酰化
药物化学
氯化物
催化作用
作者
Devaneyan Joseph,Sunwoo Lee
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-08-12
卷期号:24 (33): 6186-6191
被引量:12
标识
DOI:10.1021/acs.orglett.2c02429
摘要
Amides reacted with NaN3 to give the acyl azides in DMF at 25 °C and produce the symmetrical ureas in THF/H2O at 80 °C via the sequential reaction of acyl substitution and Curtius rearrangement. All acyl azides were also obtained from the secondary amides via sequential reaction of p-toluenesulfonyl chloride and NaN3. In addition, keto-stabilized iminophosphoranes were prepared from a one-pot reaction of amides, NaN3, and phosphines.
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