伤口愈合
脐静脉
炎症
纳米载体
再生(生物学)
口腔粘膜
人脐静脉内皮细胞
医学
药理学
癌症研究
细胞生物学
免疫学
化学
病理
药品
生物
生物化学
体外
作者
Qiangqiang Zhou,Mengqi Zhou,Guofeng Yang,Xiaofeng Sui,Changyi Li,Huaxing Xu,Yuehua Liu,Xiaoling Wei
出处
期刊:Small
[Wiley]
日期:2025-01-24
标识
DOI:10.1002/smll.202411353
摘要
Abstract Oral mucosal injuries are commonly caused by factors such as trauma, infection, or inflammation, especially in diabetic patients where healing is difficult and significantly affects quality of life. In this study, a nanocarrier system based on DNA tetrahedrons (TDN) is developed, which serve as ideal vectors due to their excellent intracellular uptake and drug delivery capabilities. By efficiently delivering miR132 into cells, the proliferation and migration of human oral mucosal fibroblasts (HOMFs) and human umbilical vein endothelial cells (HUVECs) are regulated, along with the modulation of inflammation and antioxidant processes. In the oral wound model of diabetic rats, the miR@TDN system effectively and stably delivers miR132 to the injured mucosa. By regulating the inflammatory response, promoting blood vessel regeneration, and enhancing antioxidant defense mechanisms, significant improvement in cellular repair function and acceleration of the wound healing process are observed. These findings provide a new strategy and experimental basis for the clinical treatment of oral mucosal injuries.
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