已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Clinical and patient-reported outcomes after oncoplastic versus conventional breast conserving surgery—a longitudinal, multicenter cohort study

医学 保乳手术 乳腺癌 肿瘤整形外科 乳房切除术 前瞻性队列研究 队列 队列研究 外科 乳房外科 癌症 内科学
作者
Claudia A. Bargon,Dieuwke R. Mink van der Molen,Danny A. Young‐Afat,Marilot C. T. Batenburg,Iris E. van Dam,Inge O. Baas,Miranda F. Ernst,Wiesje Maarse,Cornelis F.M. Sier,Ernst J. P. Schoenmaeckers,J. P. J. Burgmans,Rhodé M. Bijlsma,Sabine Siesling,Hinne A. Rakhorst,Marc A.M. Mureau,Femke van der Leij,Annemiek Doeksen,Helena M. Verkooijen
出处
期刊:Journal of the National Cancer Institute [Oxford University Press]
标识
DOI:10.1093/jnci/djae310
摘要

Abstract Background Oncoplastic breast conserving surgery (OP-BCS) is becoming increasingly popular to avoid mastectomy or optimize cosmetic outcomes of breast conserving surgery (BCS). Few studies have compared clinical outcomes and patient-reported outcomes (PROs) of OP-BCS to conventional BCS (C-BCS). This study aims to compare clinical outcomes and short and long-term PROs after OP-BCS and C-BCS in a large prospective breast cancer cohort. Methods Women in the prospective, multicenter UMBRELLA-breast cancer cohort who underwent OP-BCS or C-BCS were included. Clinical outcomes and PROs (measured by EORTC QLQ-C30/BR23) up to 24 months postoperatively were evaluated. Mixed-model analysis was performed to assess differences in PROs over time between groups. Results 1628 (84.9%) patients received C-BCS and 290 (15.1%) OP-BCS. After C-BCS and OP-BCS, free resection margins were obtained in 84.2% (n = 1370) and 86.2% (n = 250), respectively, reoperation for re-exision of margins <3 months occurred in 5.3% (n = 86) and 4.8% (n = 14), median time interval from surgery until adjuvant systemic therapy was 66 and 63 days, and 36 and 41 days until radiotherapy. Shortly postoperative, OP-BCS was associated with statistically significant lower mean scores for physical functioning (83.6 vs 87.2) and body image (82.8 vs 89.4) and more pain (19.8 vs 26.5) and breast symptoms (22.7 vs 30.3) than C-BCS. Body image scores remained significantly less favorable after OP-BSC than C-BCS up to 24 months postoperatively (87.8 vs 92.2). Conclusions Oncoplastic surgery safely enables BCS, but may lead to less favorable long-term body image compared to C-BCS. These findings are important for patient education and shared decision-making.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
毛123完成签到,获得积分10
4秒前
ZXD1989完成签到 ,获得积分10
7秒前
思源应助hai采纳,获得10
9秒前
星宫韩立完成签到 ,获得积分10
10秒前
星宫金魁完成签到 ,获得积分10
19秒前
英俊的铭应助小点点采纳,获得10
24秒前
gby2018完成签到,获得积分10
25秒前
虚幻的夜天完成签到 ,获得积分10
27秒前
Sunnpy完成签到 ,获得积分10
29秒前
寻道图强应助f风中的草原采纳,获得30
29秒前
小二郎应助hjj采纳,获得10
30秒前
30秒前
星辰大海应助小仙女采纳,获得10
31秒前
beloved完成签到 ,获得积分10
35秒前
LSL丶完成签到,获得积分10
38秒前
Owen应助wydjljx采纳,获得10
38秒前
42秒前
斯文败类应助LSL丶采纳,获得10
44秒前
小点点发布了新的文献求助10
46秒前
51秒前
小点点完成签到,获得积分10
54秒前
春色未软旧苔痕完成签到 ,获得积分10
55秒前
小仙女发布了新的文献求助10
57秒前
1分钟前
Shrine完成签到,获得积分10
1分钟前
1分钟前
科研通AI2S应助科研通管家采纳,获得10
1分钟前
科研通AI2S应助科研通管家采纳,获得10
1分钟前
别找了睡觉吧完成签到 ,获得积分10
1分钟前
三冬四夏发布了新的文献求助10
1分钟前
1分钟前
1分钟前
1分钟前
以菱完成签到 ,获得积分10
1分钟前
1分钟前
小马甲应助VDC采纳,获得10
1分钟前
1分钟前
YOLO完成签到 ,获得积分10
1分钟前
月光发布了新的文献求助30
1分钟前
FartKing发布了新的文献求助100
1分钟前
高分求助中
Earth System Geophysics 1000
Co-opetition under Endogenous Bargaining Power 666
Medicina di laboratorio. Logica e patologia clinica 600
Sarcolestes leedsi Lydekker, an ankylosaurian dinosaur from the Middle Jurassic of England 500
《关于整治突出dupin问题的实施意见》(厅字〔2019〕52号) 500
Language injustice and social equity in EMI policies in China 500
mTOR signalling in RPGR-associated Retinitis Pigmentosa 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3213078
求助须知:如何正确求助?哪些是违规求助? 2861888
关于积分的说明 8130903
捐赠科研通 2527823
什么是DOI,文献DOI怎么找? 1361739
科研通“疑难数据库(出版商)”最低求助积分说明 643516
邀请新用户注册赠送积分活动 615861