摘要
The Journal of DermatologyEarly View LETTER TO THE EDITOR A case of epidermal growth factor receptor–mutant lung cancer with transformation from adenocarcinoma into small cell carcinoma suggested by histological investigation of skin metastasis Haruka Omasa, Haruka Omasa orcid.org/0009-0003-8722-9798 Department of Dermatology, Keio University School of Medicine, Tokyo, JapanSearch for more papers by this authorRisa Kakuta, Corresponding Author Risa Kakuta [email protected] orcid.org/0000-0002-0581-4703 Department of Dermatology, Keio University School of Medicine, Tokyo, Japan Correspondence Risa Kakuta, Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjukuku, Tokyo 160-8582, Japan. Email: [email protected]Search for more papers by this authorHideki Terai, Hideki Terai orcid.org/0000-0002-1118-1930 Keio Cancer Center (Respiratory Medicine), Keio University School of Medicine, Tokyo, JapanSearch for more papers by this authorMiho Kawaida, Miho Kawaida orcid.org/0000-0003-0353-4246 Department of Surgical Pathology, Ito Hospital, Tokyo, JapanSearch for more papers by this authorIkuko Hirai, Ikuko Hirai orcid.org/0000-0003-3069-1546 Department of Dermatology, Keio University School of Medicine, Tokyo, JapanSearch for more papers by this authorKana Tamura, Kana Tamura Department of Dermatology, Keio University School of Medicine, Tokyo, JapanSearch for more papers by this authorYoshihiro Ito, Yoshihiro Ito orcid.org/0000-0003-3536-4819 Department of Dermatology, Keio University School of Medicine, Tokyo, JapanSearch for more papers by this authorAyano Fukushima-Nomura, Ayano Fukushima-Nomura orcid.org/0000-0002-9482-5008 Department of Dermatology, Keio University School of Medicine, Tokyo, JapanSearch for more papers by this authorMasayuki Amagai, Masayuki Amagai orcid.org/0000-0003-3314-7052 Department of Dermatology, Keio University School of Medicine, Tokyo, JapanSearch for more papers by this authorHayato Takahashi, Hayato Takahashi orcid.org/0000-0001-6768-8821 Department of Dermatology, Keio University School of Medicine, Tokyo, JapanSearch for more papers by this author Haruka Omasa, Haruka Omasa orcid.org/0009-0003-8722-9798 Department of Dermatology, Keio University School of Medicine, Tokyo, JapanSearch for more papers by this authorRisa Kakuta, Corresponding Author Risa Kakuta [email protected] orcid.org/0000-0002-0581-4703 Department of Dermatology, Keio University School of Medicine, Tokyo, Japan Correspondence Risa Kakuta, Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjukuku, Tokyo 160-8582, Japan. Email: [email protected]Search for more papers by this authorHideki Terai, Hideki Terai orcid.org/0000-0002-1118-1930 Keio Cancer Center (Respiratory Medicine), Keio University School of Medicine, Tokyo, JapanSearch for more papers by this authorMiho Kawaida, Miho Kawaida orcid.org/0000-0003-0353-4246 Department of Surgical Pathology, Ito Hospital, Tokyo, JapanSearch for more papers by this authorIkuko Hirai, Ikuko Hirai orcid.org/0000-0003-3069-1546 Department of Dermatology, Keio University School of Medicine, Tokyo, JapanSearch for more papers by this authorKana Tamura, Kana Tamura Department of Dermatology, Keio University School of Medicine, Tokyo, JapanSearch for more papers by this authorYoshihiro Ito, Yoshihiro Ito orcid.org/0000-0003-3536-4819 Department of Dermatology, Keio University School of Medicine, Tokyo, JapanSearch for more papers by this authorAyano Fukushima-Nomura, Ayano Fukushima-Nomura orcid.org/0000-0002-9482-5008 Department of Dermatology, Keio University School of Medicine, Tokyo, JapanSearch for more papers by this authorMasayuki Amagai, Masayuki Amagai orcid.org/0000-0003-3314-7052 Department of Dermatology, Keio University School of Medicine, Tokyo, JapanSearch for more papers by this authorHayato Takahashi, Hayato Takahashi orcid.org/0000-0001-6768-8821 Department of Dermatology, Keio University School of Medicine, Tokyo, JapanSearch for more papers by this author First published: 11 February 2025 https://doi.org/10.1111/1346-8138.17666Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookxLinkedInRedditWechat No abstract is available for this article. REFERENCES 1Oser MG, Niederst MJ, Sequist LV, Engelman JA. Transformation from non-small-cell lung cancer to small-cell lung cancer: molecular drivers and cells of origin. Lancet Oncol. 2015; 16: e165–e172. 10.1016/S1470-2045(14)71180-5 CASPubMedWeb of Science®Google Scholar 2Oxnard GR, Arcila ME, Sima CS, Riely GJ, Chmielecki J, Kris MG, et al. Acquired resistance to EGFR tyrosine kinase inhibitors in EGFR-mutant lung cancer: distinct natural history of patients with tumors harboring the T790M mutation. Clin Cancer Res. 2011; 17: 1616–1622. 10.1158/1078-0432.CCR-10-2692 CASPubMedWeb of Science®Google Scholar 3Ishioka K, Yasuda H, Hamamoto J, Terai H, Emoto K, Kim TJ, et al. Upregulation of FGF9 in lung adenocarcinoma Transdifferentiation to small cell lung cancer. 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