Antibacterial lanostane triterpenoids from Ganoderma tsugae

AbstractA phytochemical investigation on the 80% EtOH extract of the fruiting bodies of Ganoderma tsugae resulted into the isolation of two previously undescribed lanostane triterpenoids, 7,11-dioxo-3β-acetyloxy-26,27-dihydroxy-lanosta-8,24-diene (1) and 7,20-dioxo-3β-acetyloxy-11β,15α-dihydroxy-22,23,24,25,26,27-hexanorlanosta-8-ene (2), togeher with one known lanostane triterpenoid ganodermanontriol (3). Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy. All the triterpenoids were in vitro evaluated for their antibacterial activities against six pathogenic microorganisms. Compound 3 exhibited some activities against three Gram positive bacteria with MIC values less than 30 μg/ml.Keywords: GanodermataceaeGanoderma tsugaelanostane triterpenoidsantibacterial activity Disclosure statementNo potential conflict of interest was reported by the author(s).Additional informationFundingThe above research was made possible by the grant from the joint special fund project of the Applied Basic Research for local university in Yunnan Province [2019FH001 (-033)], Special funds for reform and development of local university supported by the Central Finance [PL201707230369].