脂肪因子
医学
内分泌学
内科学
糖尿病
2型糖尿病
食欲
2型糖尿病
胰岛素
脂肪组织
外显子
葡萄糖稳态
肥胖
胰岛素抵抗
基因
生物
遗传学
作者
Hongcui Diao,Xue Lü,Yeqiu Xu,Xiaoping Xing,Shuguang Pang
标识
DOI:10.1016/j.jdiacomp.2023.108614
摘要
Asprosin, encoded by penultimate two exons (exon 65 and exon 66) of the gene Fibrillin 1 (FBN1), has been recently discovered to be a novel hormone secreted by white adipose tissues during fasting. The glucose metabolism disorders are often accompanied by increased asprosin level. Previous research suggests that asprosin may contribute to the development of diabetes by regulating glucose homeostasis, appetite, insulin secretion, and insulin sensitivity. In this review, we summarize the recent findings from studies on asprosin and its association with Type 2 diabetes mellitus, and discusses its mechanisms from various aspects, so as to provide clinical diagnosis and treatment ideas for T2DM.
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