Strength in diversity: Widening B cell recruitment for broader vaccine protection

Generating potent neutralizing antibodies is a unifying goal of next-generation vaccines. In this issue of Immunity, Ols et al. show that multivalent nanoparticle vaccines displaying RSV F protein can enable recruitment of more diverse B cell specificities into the vaccine response, resulting in increased potency and breadth of antibody immunity to both RSV and the related human metapneumovirus. Generating potent neutralizing antibodies is a unifying goal of next-generation vaccines. In this issue of Immunity, Ols et al. show that multivalent nanoparticle vaccines displaying RSV F protein can enable recruitment of more diverse B cell specificities into the vaccine response, resulting in increased potency and breadth of antibody immunity to both RSV and the related human metapneumovirus. Multivalent antigen display on nanoparticle immunogens increases B cell clonotype diversity and neutralization breadth to pneumovirusesOls et al.ImmunitySeptember 8, 2023In BriefA mechanistic understanding of immune responses elicited by multivalent nanoparticle immunogens is lacking in higher mammals. Ols et al. show in non-human primates that humoral responses are modulated by interrelated aspects of nanoparticles: their size and valency. Nanoparticle size slowed lymphatic transport, and valency-dependent avidity improved recruitment of low-affinity B cells, increasing B cell clonotype diversity and neutralization breadth. Full-Text PDF Open Access