Optical coherence tomography (OCT) measurements and disability in multiple sclerosis (MS): A systematic review and meta-analysis

扩大残疾状况量表 医学 荟萃分析 视神经炎 神经纤维层 眼科 多发性硬化 视网膜 光学相干层析成像 内丛状层 子群分析 内科学 精神科
作者
Omid Mirmosayyeb,Mohammad Yazdan Panah,Yousef Mokary,Elham Moases Ghaffary,Hamed Ghoshouni,Robert Zivadinov,Bianca Weinstock‐Guttman,Dejan Jakimovski
出处
期刊:Journal of the Neurological Sciences [Elsevier BV]
卷期号:454: 120847-120847 被引量:2
标识
DOI:10.1016/j.jns.2023.120847
摘要

Background Studies have demonstrated that people with multiple sclerosis (pwMS) experience visual impairments and neurodegenerative retinal processes. The disability progression in pwMS may be associated with retinal changes assessed with optical coherence tomography (OCT). This meta-analysis aims at synthesizing the correlations between OCT measurements of disability in pwMS. Methods We systematically searched four databases (PubMed/MEDLINE, Embase, Scopus, and Web of Science) from inception to November 2022, then conducted a meta-analysis using a random effects model to determine the pooled correlation coefficient(r) between OCT measurements and disability scales by R version 4.2.3 with the meta version 6.2–1 package. Results From 3129 studies, 100 studies were included. Among 9051 pwMS, the female-to-male ratio was 3.15:1, with a mean age of 39.57 ± 6.07 years. The mean disease duration and Expanded Disability Status Scale (EDSS) were 8.5 ± 3.7 and 2.7 ± 1.1, respectively. Among the pooled subgroup analyses, macular ganglion cell inner plexiform layer (mGCIPL) in patients with relapsing-remitting (pwRRMS) and peripapillary retinal nerve fiber layer (pRNFL) in patients with progressive MS (pwPMS) had strong correlations with EDSS, r = −0.33 (95% CI: −0.45 to −0.20, I2 = 45%, z-score = −4.86, p < 0.001) and r = −0.20 (95% CI:-0.58 to 0.26, I2 = 76%, z-score = −0.85, p = 0.395), respectively. According to subgroup analysis on pwMS without optic neuritis (ON) history, the largest correlation was seen between EDSS and macular ganglion cell complex (mGCC): r = −0.39 (95% CI: −0.70 to 0.04, I2 = 79%, z-score = −1.79, p = 0.073). Conclusion OCT measurements are correlated with disability in pwMS, and they can complement the comprehensive neurological visit as an additional paraclinical test.
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