Connexins and blood-brain barrier: Beyond the gap

In this issue of Neuron, Zhan, Meng, et al. 1 Zhan R. Meng X. Tian D. Xu J. Cui H. Yang J. Xu Y. Shi M. Xue J. Yu W. et al. NAD+ rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis. Neuron. 2023; 111: 3634-3649https://doi.org/10.1016/j.neuron.2023.08.010 Abstract Full Text Full Text PDF PubMed Scopus (4) Google Scholar explore the non-canonical roles of connexin-43 in brain endothelial cells and connect its faltering expression to the depletion of nicotinamide adenine dinucleotide (NAD), mitochondrial stress, and blood-brain barrier rupture. In this issue of Neuron, Zhan, Meng, et al. 1 Zhan R. Meng X. Tian D. Xu J. Cui H. Yang J. Xu Y. Shi M. Xue J. Yu W. et al. NAD+ rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis. Neuron. 2023; 111: 3634-3649https://doi.org/10.1016/j.neuron.2023.08.010 Abstract Full Text Full Text PDF PubMed Scopus (4) Google Scholar explore the non-canonical roles of connexin-43 in brain endothelial cells and connect its faltering expression to the depletion of nicotinamide adenine dinucleotide (NAD), mitochondrial stress, and blood-brain barrier rupture. NAD+ rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axisZhan et al.NeuronSeptember 7, 2023In BriefZhan et al. establish a central role for the CX43-PARP1-NAD+ pathway in Cdh5+ BBB-related cell clusters in vascular aging and reveal a potential therapeutic strategy to protect BBB functions during aging. Full-Text PDF