Dupilumab to treat drug reaction with eosinophilia and systemic symptoms: A case series

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a type IV hypersensitivity reaction manifesting with internal organ involvement, lymphadenopathy, hematologic abnormalities, and cutaneous lesions.1 Common culprits include allopurinol, antiepileptics, and antibiotics. Systemic corticosteroids are the mainstay of active intervention for this severe cutaneous adverse reaction (SCAR); however, this is associated with negative side effects, particularly with prolonged use, as is often required for DRESS.