小RNA
细胞外小泡
心力衰竭
微泡
胞外囊泡
生物发生
细胞外
细胞内
发病机制
生物信息学
生物
医学
细胞生物学
免疫学
内科学
遗传学
基因
作者
Changgeng Tian,James W. Ziegler,Irving H. Zucker
出处
期刊:Cells
[MDPI AG]
日期:2023-08-25
卷期号:12 (17): 2145-2145
标识
DOI:10.3390/cells12172145
摘要
Extracellular vesicles (EVs) are emerging mediators of intracellular and inter-organ communications in cardiovascular diseases (CVDs), especially in the pathogenesis of heart failure through the transference of EV-containing bioactive substances. microRNAs (miRNAs) are contained in EV cargo and are involved in the progression of heart failure. Over the past several years, a growing body of evidence has suggested that the biogenesis of miRNAs and EVs is tightly regulated, and the sorting of miRNAs into EVs is highly selective and tightly controlled. Extracellular miRNAs, particularly circulating EV-miRNAs, have shown promising potential as prognostic and diagnostic biomarkers for heart failure and as therapeutic targets. In this review, we summarize the latest progress concerning the role of EV-miRNAs in HF and their application in a therapeutic strategy development for heart failure.
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