隆突性皮肤纤维肉瘤
医学
入射(几何)
回顾性队列研究
危险系数
流行病学
比例危险模型
队列
内科学
外科
病理
置信区间
光学
物理
作者
David D. Xiong,Jeremy S. Bordeaux
出处
期刊:Dermatologic Surgery
[Ovid Technologies (Wolters Kluwer)]
日期:2023-11-14
卷期号:49 (12): 1096-1103
被引量:1
标识
DOI:10.1097/dss.0000000000004018
摘要
Recent changes in the incidence and survival of dermatofibrosarcoma protuberans (DFSP) have not been described.To characterize the incidence and survival of DFSP.A retrospective cohort study of patients with DFSP from 2000 to 2020 in the Surveillance, Epidemiology, and End Results database was performed. Cox and Fine-Gray regression models were used to assess overall and DFSP-specific survival.The incidence of DFSP has not changed from 2000 to 2020 with 4.6 cases/million person-years, with higher rates in dark-skinned and middle-age individuals. Factors associated with overall mortality in DFSP patients include advanced age ( p < .0001), male sex (hazard ratio [HR] 1.8, p < .0001), larger tumors (HR 1.002 per millimeter, p < .001), lower household income (HR 1.8, p = .0002), and lower extremity location (HR 1.7, p = .008). Mohs surgery is associated with improved overall survival (HR 0.4, p = .02). Large tumor size (6.0+ cm, HR 6.7, p = .01) and advanced age (age 80+ years, HR 21.3, p = .003) were associated with worse DFSP-specific mortality.Dermatofibrosarcoma protuberans incidence has remained constant from 2000 to 2020. Increasing age and tumor size, decreased income, male sex, and lower extremity location are associated with worsened survival. Mohs surgery is associated with improved overall survival. Increased age and tumor size are associated with worsened DFSP-specific mortality.
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