Rising resistance: antibiotic choices for Helicobacter pylori infection

Asia is an area characterised by a notably elevated age-standardised rate of gastric cancer, 1 Sekiguchi M Oda I Matsuda T Saito Y Epidemiological trends and future perspectives of gastric cancer in Eastern Asia. Digestion. 2022; 103: 22-28 Crossref PubMed Scopus (34) Google Scholar exacerbated by a concomitantly high prevalence of Helicobacter pylori infection. 2 Hooi JKY Lai WY Ng WK et al. Global prevalence of Helicobacter pylori infection: systematic review and meta-analysis. Gastroenterology. 2017; 153: 420-429 Summary Full Text Full Text PDF PubMed Scopus (1712) Google Scholar Effective strategies to eradicate H pylori are therefore imperative. For these reasons, the systematic review and meta-analysis done by Tzu-Chan Hong and colleagues, 3 Hong T-C El-Omar E-M Kuo Y-T et al. Primary antibiotic resistance of Helicobacter pylori in the Asia-Pacific region between 1990 and 2022: an updated systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2023; (published online Nov 13.)https://doi.org/10.1016/S2468-1253(23)00281-9 Summary Full Text Full Text PDF PubMed Scopus (1) Google Scholar in which the primary antibiotic resistance of H pylori was assessed in the Asia-Pacific region, has particular utility. Primary antibiotic resistance of Helicobacter pylori in the Asia-Pacific region between 1990 and 2022: an updated systematic review and meta-analysisTreatment guidelines should be adapted in response to the rising primary resistance of key antibiotics for H pylori eradication. A global policy to control and monitor the antibiotic resistance of H pylori is urgently needed. Full-Text PDF