已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Reproductive outcomes with delayed blastocyst development: the clinical value of day 7 euploid blastocysts in frozen embryo transfer cycles

胚泡 胚胎 男科 受精 胚胎移植 妇科 活产 胚泡移植 妊娠率 生物 怀孕 胚胎发生 化学 医学 遗传学 精子
作者
A Abdala,Ibrahim Elkhatib,A Bayram,Ahmed El-Damen,Laura Melado,D Nogueira,Barbara Lawrenz,Human M. Fatemi
出处
期刊:Zygote [Cambridge University Press]
卷期号:31 (6): 588-595
标识
DOI:10.1017/s0967199423000485
摘要

Summary Embryos of optimal development reach blastocyst stage 116 ± 2 h after insemination. Usable D7 blastocysts represent nearly 5% of embryos in IVF with acceptable pregnancy and live birth rates, however data are still limited. Therefore, this study aimed to analyze the ongoing pregnancy rate (OPR) of D7 blastocysts in single euploid frozen embryo transfer (FET) cycles. An observational study was performed including 1527 FET cycles with blastocysts biopsied on D5 ( N = 855), D6 ( N = 636) and D7 ( N = 36). Blastocysts were classified as good (AA/AB/BA), fair (BB) or poor (AC/BC/CC/CA/CB) (Gardner scoring). FETs were performed in natural cycles (NC) or hormone replacement therapy (HRT) cycles. Patient’s age differed significantly between D5, D6 and D7 blastocysts FET cycles (33.2 ± 5.6, 34.4 ± 5.3 and 35.9 ± 5.2, P < 0.001). OPRs were higher when D5 euploid blastocysts were transferred compared with D6 and D7 (56.0% vs. 45.3% and 11.1%, P < 0.001). Poor quality blastocysts were predominant in D7 blastocyst FET cycles (good quality: 35.4%, 27.2%, 5.6%; fair quality: 52.1%, 38.5%, 11.1%; poor quality: 12.5%, 34.3%, 83.3%, P < 0.001 for D5, D6 and D7 blastocysts; respectively). OPR was significantly reduced by D7 blastocyst FETs (OR = 0.23 [0.08;0.62], P = 0.004), patient’s BMI (OR = 0.96 [0.94;0.98], P < 0.001), HRT cycles (OR = 0.70 [0.56;0.88], P = 0.002) and poor quality blastocysts (OR = 0.33 [0.24;0.45], P < 0.001). OPR is significantly reduced with D7 compared with D5/D6 euploid blastocysts in FET cycles. The older the patient, the more likely they are to have an FET cycle with blastocysts biopsied on D7, therefore culturing embryos until D7 can be a strategy to increase OPR outcomes in patients ≥38 years.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
猫瓜西发布了新的文献求助10
刚刚
刚刚
贰鸟应助咋取名字采纳,获得10
刚刚
刚刚
刚刚
葛粑粑完成签到 ,获得积分10
1秒前
2秒前
5秒前
mxm12138发布了新的文献求助30
6秒前
liuyue发布了新的文献求助10
7秒前
11秒前
11秒前
Orange应助Lidocaine采纳,获得10
12秒前
12秒前
TRY发布了新的文献求助10
13秒前
Fezz完成签到 ,获得积分10
15秒前
18秒前
19秒前
19秒前
22秒前
23秒前
领导范儿应助俏皮的白柏采纳,获得10
27秒前
28秒前
28秒前
Lidocaine发布了新的文献求助10
28秒前
wiky完成签到,获得积分10
32秒前
大个应助ma采纳,获得10
32秒前
希特勒完成签到,获得积分20
32秒前
zhongu发布了新的文献求助10
32秒前
32秒前
万能图书馆应助HongY采纳,获得10
34秒前
34秒前
Lidocaine完成签到,获得积分10
34秒前
希特勒发布了新的文献求助10
37秒前
39秒前
39秒前
1218完成签到 ,获得积分10
42秒前
47秒前
48秒前
苏和杨发布了新的文献求助10
50秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989811
求助须知:如何正确求助?哪些是违规求助? 3531927
关于积分的说明 11255560
捐赠科研通 3270706
什么是DOI,文献DOI怎么找? 1805035
邀请新用户注册赠送积分活动 882181
科研通“疑难数据库(出版商)”最低求助积分说明 809190