化学
催化作用
缺氧(环境)
氧化还原
光催化
组合化学
药品
癌症研究
药物化学
光化学
氧气
生物化学
有机化学
药理学
医学
作者
Li Wei,Rajesh Kushwaha,Anyi Dao,Zhongxian Fan,Samya Banerjee,Huaiyi Huang
摘要
A novel axisymmetric bis-tridentate Ir(III) photocatalyst (Ir3) with synergetic type I/II photosensitization and photocatalytic activity was reported. Ir3 exhibited high photocytotoxicity toward drug-resistant cancer cells under normoxia and hypoxia. The photoactivated anticancer mechanism of Ir3 were investigated in detail. Overall, this new photo-redox catalyst can overcome hypoxia and drug resistance-related problems in clinical anticancer therapy.
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