免疫系统
髓源性抑制细胞
当归
CD8型
体内
体外
髓样
脾脏
免疫学
化学
细胞生物学
生物
抑制器
医学
生物化学
中医药
生物技术
替代医学
病理
基因
作者
Jie Shen,Mengyu Zhang,Ke Zhang,Yahan Qin,Meifang Liu,Shuai Liang,Daquan Chen,Meiyu Peng
标识
DOI:10.3389/fimmu.2022.989230
摘要
Angelica polysaccharide (APS) is a polysaccharide extracted from Angelica sinensis and it is one of the main active components of Angelica sinensis. Many studies have demonstrated that APS can promote the activation and function of a variety of immune cells and is recognized as an immune enhancer, but the regulatory effect of APS on myeloid-derived suppressor cells (MDSC) is still unclear. In this study, we investigated the effects of APS on MDSC proliferation, differentiation and function through in vivo and in vitro experiments. In vitro, our results showed that APS promoted the proliferation, differentiation and immunosuppressive function of MDSC through STAT1 and STAT3 signaling pathways, and positively correlated with the expression level of Mannose receptor (MR, also known as CD206) and in a concentration-dependent manner on APS. In vivo, APS up-regulated T cells, γδT cells, CD8+T cells, natural killer cells, monocytes/macrophages, and granulocytes in the peripheral blood and spleen of mice to varying degrees and was accompanied by the same degree of increase in the proportion of MDSC. That reminds to the clinician that when applying APS as treatment they should pay attention to its possible side effects of increasing the quantity and function of MDSC, in order to increase its efficacy.
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