阿比坦
立体化学
化学
二萜
萜类
萜烯
鼠尾草
戒指(化学)
传统医学
有机化学
医学
作者
Jianjun Zhao,Shu-Zong Du,Kun Hu,Yali Hu,Fan Xia,Yan-Song Ye,Jian Yang,Yin Nian,Gang Xu
标识
DOI:10.1016/j.cclet.2022.08.017
摘要
Nineteen diterpenoids, including saldigitin A (1) bearing an unprecedented 10-methylated 6/7/6 carbon ring system, two new icetexanes (2, 3), and two new nor-abietanes (5, 6) were characterized from the roots of Salvia digitaloides. Their structures were elucidated by the analysis of the spectroscopic data, X-ray crystallography, and TDDFT calculations of ECD spectra. The novel architecture of 1 should be biogenetically derived through the cleavage and re-cyclization of the B/C rings from the normal abietane skeleton. Biologically, 1–5 exhibited noticeable inhibitions on Cav3.1 low voltage-gated Ca2+ channel (LVGCC), with IC50 values in the range of 3.43–11.70 µmol/L. They are the first example of diterpenoids with 6/7/6 carbon rings system as Cav3.1 antagonists.
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