Effects of salidroside on exercise tolerance of mice under high altitude hypoxia environment

红景天苷 丙二醛 谷胱甘肽 糖原 氧化应激 缺氧(环境) 内分泌学 化学 超氧化物歧化酶 内科学 生物化学 生物 药理学 氧气 医学 有机化学
作者
Qin Ningning,Hua Xie,Anpeng Zhao,Jing Wang,Yuemei Sun,Wenbin Li,Rong Wang
出处
期刊:Journal of Zhejiang University (Medical Sciences) [China Science Publishing & Media Ltd.]
卷期号:51 (4): 397-404 被引量:8
标识
DOI:10.3724/zdxbyxb-2022-0158
摘要

To investigate the effect of salidroside on the exercise tolerance of mice under high altitude hypoxia environment.C57BL/6J healthy male mice were randomly divided into normoxia control group, model control group, Rhodiola rosea capsule group and salidroside low-dose (5 mg/kg), medium-dose (10 mg/kg) and high-dose (20 mg/kg) groups, with 15 mice in each group. After 3 days, all groups (except the normoxia control group) entered a plateau with an altitude of 4010 m. After 1 day of hypoxia exposure, the exhausted swimming test was performed to determine the exhaustive time of mice; the pathological changes of liver and muscle tissue were observed with hematoxylin and eosin staining. The levels of malondialdehyde (MDA), hydrogen peroxide (H 2O 2), glutathione (GSH), total superoxide dismutase (T-SOD), glycogen, lactate and ATPase were measured and compared among groups.Compared with the normoxia control group, the exhaustive swimming time of the model control group was shortened ( P<0.05), the liver tissue and muscle tissue were pathologically damaged, the level of oxidative stress was significantly increased, the levels of sodium potassium ATPase and calcium magnesium ATPase were significantly increased. Compared with the model control group, the exhaustive swimming time of the mice in the Rhodiola rosea capsule group and salidroside groups was significantly prolonged ( P<0.05). The oxidative stress injury was alleviated, the contents of MDA, H 2O 2 and lactic acid in liver and muscle tissues decreased, the contents of GSH, liver glycogen and muscle glycogen increased, and the activities of T-SOD and ATPase increased (all P<0.05).Salidroside has significant anti-fatigue activity, and its anti-fatigue effect is related to the reduction of oxidative stress damage, the reduction of the accumulation of undesirable metabolites and the increase in the reserve of energy substances.
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