表面改性
光热治疗
缩水甘油
阿霉素
体内
单体
材料科学
药物输送
共价键
化学
组合化学
纳米技术
有机化学
聚合物
医学
外科
生物技术
物理化学
化疗
生物
催化作用
作者
Ievgen S. Donskyi,Xin Huang,Natalie Wichmann,Obida Bawadkji,Rameez Ahmed,Philip Nickl,Svenja Ehrmann,Jörg Radnik,Katharina Achazi,Haishi Qiao,Mohsen Adeli
出处
期刊:ACS applied nano materials
[American Chemical Society]
日期:2022-09-08
卷期号:5 (9): 13417-13424
被引量:6
标识
DOI:10.1021/acsanm.2c03093
摘要
Here, we report a one-pot, straightforward, and efficient method for the covalent functionalization of black phosphorous (BP) nanosheets with biopolymers on a gram scale. l-lactide and glycidol monomers were stepwise copolymerized onto the surface of exfoliated BP resulting in highly water-soluble functional nanosheets (BP-PLA-PG). In contrast to pristine BP, their functionalized counterparts did not degrade under ambient conditions and were stable for several weeks. Owing to their stability, efficient photothermal effect, and low toxicity, BP-PLA-PG sheets were loaded with doxorubicin (DOX), and their anticancer effect was investigated in vitro and in vivo. The laser-triggered release of DOX, in combination with the photothermal effect of the functionalized BP sheets, manifested in strong antitumor effects in animal studies. One-pot straightforward functionalization, high loading capacity, low toxicity, excellent water dispersibility and stability, as well as high functionality, support BP-PLA-PG as a promising vector for the future biomedical applications, including targeted drug delivery and bioimaging.
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