螺旋霉素
弓形虫病
寄生虫寄主
肺
壳聚糖
弓形虫
免疫学
化学
微生物学
病毒学
医学
生物
内科学
抗生素
抗体
生物化学
红霉素
万维网
计算机科学
作者
Dalia Osama,Nadia El-Dib,H M Khattab,Hassan Ibrahim,Mona M Khater,Ehab Kotb Elmahallawy,Ashraf Barakat
出处
期刊:Egyptian Journal of Veterinary Science
日期:2024-01-13
卷期号:55 (4): 1151-1164
标识
DOI:10.21608/ejvs.2024.253903.1708
摘要
HE present study was designed to evaluate the use of nanoparticles in improving the antiparasitic effect of Spiramycin, Spiramycin loaded on Carboxymethyl chitosan nanoparticles (CMC Np), ) on experimental toxoplasmosis.Different doses of the drugs under study were assessed using parasitological and histopathological investigations.For this purpose, a total of 38 female Swiss albino mice were divided as follows; Group 1 (5 mice) as a negative control group (non-infected, non-treated group).Group 2 (5 mice) as a positive control group (infected, nontreated group); Group 3: In this group, 28 mice were infected, and treatment started after 10-15 days post-infection for 1 week on a daily basis.The third group was subdivided into four subgroups (7 mice for each), which were treated as follows; subgroup (3a); the infected mice treated with Spiramycin alone in a dose of 100 mg/ kg /day orally, sub group (3b); the infected mice treated with CMC Np orally.Sub group (3c); the infected mice treated with Spiramycin loaded on CMC Np of concentration of 0.35 gm/100 ml H 2 O (low dose-LD) orally.Subgroup (3d); the infected mice treated with Spiramycin loaded on CMC Np of concentration of 0.70 g/ 100 ml H 2 O (High dose-HD) orally.At the end of the experiment, liver and lung were dissected for detection of the parasite burden and the histopathological examination of the tissues was carried out to allocate the histopathological findings in these organs and detection of tissue cysts.Remarkably, a noticeable decrease in parasitic load was stated pooled with renovation of histopathological alterations were prominent with treated groups in association with infected non-treated group.
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